Vacuolar Protein Sorting 29 Homolog (S. Cerevisiae) (VPS29) (C-Term) antibody

Details for Product No. ABIN351326
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DC15, PEP11, AW049835, 2010015D08Rik, ATVPS29, MAIGO 1, VACUOLAR PROTEIN SORTING 29, VPS29, fb06g05, wu:fb06g05, zgc:56191, zgc:86638, VPT6, DDBDRAFT_0188107, DDBDRAFT_0234192, DDB_0188107, DDB_023419 ... show more
DC15, PEP11, AW049835, 2010015D08Rik, ATVPS29, MAIGO 1, VACUOLAR PROTEIN SORTING 29, VPS29, fb06g05, wu:fb06g05, zgc:56191, zgc:86638, VPT6, DDBDRAFT_0188107, DDBDRAFT_0234192, DDB_0188107, DDB_0234192, 17.m07782, vps29 show less
(6), (6), (2), (1)
Human, Mouse (Murine), Rat (Rattus)
(13), (5), (5), (3), (1)
(12), (6), (1)
Immunohistochemistry (IHC), Western Blotting (WB)
(12), (10), (4), (2)
Pubmed 6 references available
Catalog no. ABIN351326
Quantity 500 µg
454.67 $   Plus shipping costs $45.00
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Immunogen A synthetic peptide from the c-terminal region of mouse VPS29 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat, human, chicken, zebra fish and xenopus.
Specificity Specific for CACNA2D3.
Purification IgG
Alternative Name Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29, VPS29)
Background Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro).
Catalytic activity: O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor: Binds 2 zinc ions per subunit.
Subcellular location: Cytoplasm. Membrane, Peripheral membrane protein. Endosome membrane, Peripheral membrane protein. Also known as: Vacuolar protein sorting-associated protein 29, Vesicle protein sorting 29, VPS29.
UniProt Q8CFG5
Research Area Signaling
Application Notes A concentration of 10-50 µg/mL is recommended.
The optimal concentration should be determined by the end user.
Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Handling Advice Avoid freeze and thaw cycles.
Storage -20 °C
Storage Comment Maintain the lyophilised/reconstituted antibodies frozen at -20 °C for long term storage and refrigerated at 2-8 °C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability.
Expiry Date 12 months
General Haft, de la Luz Sierra, Bafford et al.: "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes." in: Molecular biology of the cell, Vol. 11, Issue 12, pp. 4105-16, 2000 (PubMed).

Wiemann, Weil, Wellenreuther et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs...." in: Genome research, Vol. 11, Issue 3, pp. 422-35, 2001 (PubMed).

Vergues, Luton, Gruber et al.: "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor." in: Nature cell biology, Vol. 6, Issue 8, pp. 763-9, 2004 (PubMed).

Collins, Skinner, Watson et al.: "Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly." in: Nature structural & molecular biology, Vol. 12, Issue 7, pp. 594-602, 2005 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome...." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Hierro, Rojas, Rojas et al.: "Functional architecture of the retromer cargo-recognition complex." in: Nature, Vol. 449, Issue 7165, pp. 1063-7, 2007 (PubMed).

Hosts (12), (6), (1)
Reactivities (13), (5), (5), (3), (1)
Applications (12), (10), (4), (2)
Epitopes (6), (6), (2), (1)
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