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Details for Product No. ABIN351326

Vacuolar Protein Sorting 29 Homolog (S. Cerevisiae) (VPS29) (C-Term) antibody

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Antigen
Synonyms
DC15, PEP11, AW049835, 2010015D08Rik, ATVPS29, MAIGO 1, VACUOLAR PROTEIN SORTING 29, VPS29, fb06g05, wu:fb06g05, zgc:56191, zgc:86638, VPT6, DDBDRAFT_0188107, DDBDRAFT_0234192, DDB_0188107, DDB_023419 ... show more
Epitope
»Alternatives C-Term
Reactivity
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 6 references available
Catalog no. ABIN351326
Quantity 500 µg
Price
454.67 $   Plus shipping costs $45.00
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Availability Will be delivered in 7 to 8 Business Days
Immunogen A synthetic peptide from the c-terminal of mouse Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29, VPS29) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat, human, chicken, zebra fish and xenopus.
Isotype IgG
Specificity Appears to be specific for VPS29.
Purity IgG
Alternative Name Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29, VPS29)
Background Function: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro).
Catalytic activity: O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor: Binds 2 zinc ions per subunit.
Subcellular location: Cytoplasm. Membrane, Peripheral membrane protein. Endosome membrane, Peripheral membrane protein. Also known as: Vacuolar protein sorting-associated protein 29, Vesicle protein sorting 29, VPS29.
UniProt Q9QZ88
Application Notes IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not tested in other applications.
Restrictions For Research Use only
Format Lyophilized
Storage -20 °C
Haft, de la Luz Sierra, Bafford et al.: "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes." in: Molecular biology of the cell, Vol. 11, Issue 12, pp. 4105-16, 2000 (PubMed).

Wiemann, Weil, Wellenreuther et al.: "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." in: Genome research, Vol. 11, Issue 3, pp. 422-35, 2001 (PubMed).

Vergues, Luton, Gruber et al.: "The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor." in: Nature cell biology, Vol. 6, Issue 8, pp. 763-9, 2004 (PubMed).

Collins, Skinner, Watson et al.: "Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly." in: Nature structural & molecular biology, Vol. 12, Issue 7, pp. 594-602, 2005 (PubMed).

Carninci, Kasukawa, Katayama et al.: "The transcriptional landscape of the mammalian genome." in: Science (New York, N.Y.), Vol. 309, Issue 5740, pp. 1559-63, 2005 (PubMed).

Hierro, Rojas, Rojas et al.: "Functional architecture of the retromer cargo-recognition complex." in: Nature, Vol. 449, Issue 7165, pp. 1063-7, 2007 (PubMed).

Alternatives for antigen "Vacuolar Protein Sorting 29 Homolog (S. Cerevisiae) (VPS29)", type "Antibodies"
Hosts (14), (8), (1)
Reactivities (16), (7), (5), (5), (1)
Applications (15), (13), (6), (2), (1), (1), (1)
Epitopes (6), (6), (2), (1)
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