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Basic Cytokeratin antibody

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Chicken, Cow (Bovine), Human, Mouse (Murine), Rabbit, Rat (Rattus)
(17), (16), (7), (7), (5), (5), (4), (3), (3), (1), (1)
Clonality (Clone)
Monoclonal ()
(1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(12), (11), (10), (8), (6), (6), (2), (1), (1)
Pubmed 8 references available
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Quantity 0.5 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone AE3
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human, Rabbit, Mouse, Rat, Bovine and Chicken.
Purification Purified
Background Cytokeratins are intermediate filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue There are two types of Cytokeratins: the low weight, acidic type I cytokeratins and the high weight, basic or neutral type II. Cytokeratins are usually found in pairs comprising a type I Cytokeratin and a type II cytokeratin. The high molecular weight cytokeratins, which are the basic or neutral cytokeratins, comprise subtypes CK1 (67), CK2 (65.5), CK3 (64), CK4 (59), CK5 (58), CK6 (56), CK7 (54), CK8 (52.5) and CK9. The low molecular weight cytokeratins, which are the acidic cytokeratins, comprise subtypes CK10 (56.5), CK12 (56), CK13 (53), CK14 (50), CK16( 48), CK17 (46), CK18 (45), CK19(48) and CK20(46).
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer 0.09 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Background publications Herbert, Uhler: "Biosynthesis of polyprotein precursors to regulatory peptides." in: Cell, Vol. 30, Issue 1, pp. 1-2, 1982 (PubMed).

Shi, Goodman, Bhan et al.: "Immunohistochemical study of nasopharyngeal carcinoma using monoclonal keratin antibodies." in: The American journal of pathology, Vol. 117, Issue 1, pp. 53-63, 1984 (PubMed).

Battifora, Sheibani, Tubbs et al.: "Antikeratin antibodies in tumor diagnosis. Distinction between seminoma and embryonal carcinoma." in: Cancer, Vol. 54, Issue 5, pp. 843-8, 1984 (PubMed).

Woodcock-Mitchell, Eichner, Nelson et al.: "Immunolocalization of keratin polypeptides in human epidermis using monoclonal antibodies." in: The Journal of cell biology, Vol. 95, Issue 2 Pt 1, pp. 580-8, 1983 (PubMed).

Huvos, Woodard, Heilweil: "Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients." in: The American journal of surgical pathology, Vol. 10, Issue 1, pp. 9-18, 1986 (PubMed).

Sun, Tseng, Huang et al.: "Monoclonal antibody studies of mammalian epithelial keratins: a review." in: Annals of the New York Academy of Sciences, Vol. 455, pp. 307-29, 1986 (PubMed).

Spagnolo, Michie, Crabtree et al.: "Monoclonal anti-keratin (AE1) reactivity in routinely processed tissue from 166 human neoplasms." in: American journal of clinical pathology, Vol. 84, Issue 6, pp. 697-704, 1986 (PubMed).

Collin, Moll, Kubicka et al.: "Characterization of human cytokeratin 2, an epidermal cytoskeletal protein synthesized late during differentiation." in: Experimental cell research, Vol. 202, Issue 1, pp. 132-41, 1992 (PubMed).

Catalog No. ABIN356305
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