anti-GFAP antibody (Glial Fibrillary Acidic Protein)

Details for Product anti-GFAP Antibody No. ABIN356477
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Synonyms GFAP, AI836096, cb345, etID36982.3, gfapl, wu:fb34h11, wu:fk42c12, xx:af506734, zgc:110485
Caprinae, Cow (Bovine), Guinea Pig, Human, Mouse (Murine), Pig (Porcine), Rat (Rattus), Sheep (Ovine)
(536), (166), (162), (75), (62), (17), (14), (11), (10), (8), (6), (5), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
(325), (292), (29), (24), (4), (3), (2)
This GFAP antibody is un-conjugated
(25), (22), (20), (13), (13), (13), (6), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1)
Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(504), (301), (180), (160), (158), (141), (77), (43), (30), (20), (12), (10), (9), (8), (8), (6), (6), (5), (4), (3), (2), (2), (1), (1)
Pubmed 6 references available
Quantity 0.5 mL
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Immunogen Purified Human GFAP.
Isotype IgG
Specificity This antibody stains astrocytes, glial cells, ependymal cells and their corresponding tumors. In the peripheral nervous system , it stains Schwann cells, satellite and enteric glial cells. This antibody distinguishes neoplasm of astrocytes origin from other neoplasm of CNS.
Cellular Localization: Cytoplasmic.
Cross-Reactivity (Details) Species reactivity (tested):Human, Bovine, Porcine, Ovine, Caprinae, Guinea Pig, Rat and Mouse.
Purification Protein A Chromatography
Alternative Name GFAP (GFAP Antibody Abstract)
Background Gilial Fibrillary acidic protein (GFAP), a 51 kDa an intermediate filament protein is closely related to non-epithelial family members, Vimentin, desmin and peripherin, which are all involved in structure and function of cell cytoskeleton. GFAP is expressed in central nervous system (CNS) in the astrocytes cells, functioning in cellular processes e.g. cell structure, movements, cell communication, brain processes and brain functions.Synonyms: Glial Fibrillary Acidic Protein
Gene ID 2670
NCBI Accession NP_001124491
UniProt P14136
Research Area Stem Cells, Cytoskeleton, Glia marker, Cell/Tissue Markers, Neurology
Application Notes Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-FixedParaffin-Embedded (FFPE) tissue sections and cell smears): 1/50-1/200 usingstreptavidinapprox. biotin system or polymer system. Immunofluorescence. Recommended Positive Control: Human brain or astrocytoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 2.0 mg/mL
Buffer PBS, pH 7.4, 0.05 % Sodium Azide, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Background publications Brillaud, Piotrowski, de Seze: "Effect of an acute 900MHz GSM exposure on glia in the rat brain: a time-dependent study." in: Toxicology, Vol. 238, Issue 1, pp. 23-33, 2007 (PubMed).

Eng, Ghirnikar, Lee: "Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000)." in: Neurochemical research, Vol. 25, Issue 9-10, pp. 1439-51, 2001 (PubMed).

Rutka, Murakami, Dirks et al.: "Role of glial filaments in cells and tumors of glial origin: a review." in: Journal of neurosurgery, Vol. 87, Issue 3, pp. 420-30, 1997 (PubMed).

Liedtke, Edelmann, Bieri et al.: "GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination." in: Neuron, Vol. 17, Issue 4, pp. 607-15, 1996 (PubMed).

Fuchs, Weber: "Intermediate filaments: structure, dynamics, function, and disease." in: Annual review of biochemistry, Vol. 63, pp. 345-82, 1994 (PubMed).

Kawahara, Oda, Ooi et al.: "Expression of glial fibrillary acidic protein (GFAP) in peripheral nerve sheath tumors. A comparative study of immunoreactivity of GFAP, vimentin, S-100 protein, and neurofilament in 38 schwannomas and 18 neurofibromas." in: The American journal of surgical pathology, Vol. 12, Issue 2, pp. 115-20, 1988 (PubMed).

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Catalog No. ABIN356477
253.00 $
Plus shipping costs $45.00
0.5 mL
253.00 $

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