Eomesodermin (EOMES) (N-Term) antibody

Details for Product No. ABIN357827
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Antigen
Synonyms EOMES, tbr2, xeomes, eom, eomes, TBR2, C77258, TBR-2, Tbr2
Epitope
N-Term
(23), (9), (4), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(54), (23), (15), (13), (12), (2)
Host
Rabbit
(45), (7), (2), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(47), (26), (10), (6), (4), (3), (1), (1)
Pubmed 4 references available
Quantity 0.4 mL
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Catalog No. ABIN357827
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human EOMES.
Specificity This antibody detects EOMES (N-term).
Purification Protein A Chromatography followed by peptide affinity purification.
Alternative Name EOMES / TBR2
Background This protein is a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar protein disrupted in mice is shown to be essential during trophoblast development and gastrulation.
Alternate names: Eomesodermin homolog, T-box brain protein 2, T-brain-2
Molecular Weight 72613 Da
Gene ID 8320, 9606
UniProt O95936
Application Notes ELISA: 1/1,000. Western blot: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Eomesodermin (EOMES) (N-Term) antibody anti-Eomesodermin (EOMES) (N-Term) antibody
Background publications Yi, Terrett, Li et al.: "Identification, mapping, and phylogenomic analysis of four new human members of the T-box gene family: EOMES, TBX6, TBX18, and TBX19." in: Genomics, Vol. 55, Issue 1, pp. 10-20, 1999 (PubMed).

Kimura, Nakashima, Ueno et al.: "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain." in: Brain research. Developmental brain research, Vol. 115, Issue 2, pp. 183-93, 1999 (PubMed).

Intlekofer, Takemoto, Wherry et al.: "Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin." in: Nature immunology, Vol. 6, Issue 12, pp. 1236-44, 2005 (PubMed).

Baala, Briault, Etchevers et al.: "Homozygous silencing of T-box transcription factor EOMES leads to microcephaly with polymicrogyria and corpus callosum agenesis." in: Nature genetics, Vol. 39, Issue 4, pp. 454-6, 2007 (PubMed).

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