Synuclein, alpha Interacting Protein (SNCAIP) (C-Term) antibody

Details for Product No. ABIN359008
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Antigen
Synonyms sncaip, MGC88953, SNCAIP, LOC100221074, SYPH1, Sph1, Syph1, 2810407O15Rik, 4933427B05Rik, BB104594
Epitope
C-Term
(11), (5), (3), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(46), (16), (14), (12), (12), (12), (12), (12), (1)
Host
Rabbit
(35), (9), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(35), (15), (14), (10), (9), (3), (1), (1), (1)
Pubmed 9 references available
Quantity 0.4 mL
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Catalog No. ABIN359008
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the C-terminal region of human Synphilin-1.
Specificity This antibody reacts to Synphilin-1 (SNCAIP).
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name Synphilin 1 / SNCAIP
Background Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson disease
Alternate names: Alpha-synuclein-interacting protein, Sph1, Synphilin-1
Gene ID 9627
NCBI Accession NP_005451
UniProt Q9Y6H5
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Engelender, Kaminsky, Guo et al.: "Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions." in: Nature genetics, Vol. 22, Issue 1, pp. 110-4, 1999 (PubMed).

Kawamata, McLean, Sharma et al.: "Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations." in: Journal of neurochemistry, Vol. 77, Issue 3, pp. 929-34, 2001 (PubMed).

Chung, Zhang, Lim et al.: "Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease." in: Nature medicine, Vol. 7, Issue 10, pp. 1144-50, 2001 (PubMed).

Junn, Lee, Suhr et al.: "Parkin accumulation in aggresomes due to proteasome impairment." in: The Journal of biological chemistry, Vol. 277, Issue 49, pp. 47870-7, 2002 (PubMed).

Marx, Holzmann, Strauss et al.: "Identification and functional characterization of a novel R621C mutation in the synphilin-1 gene in Parkinson's disease." in: Human molecular genetics, Vol. 12, Issue 11, pp. 1223-31, 2003 (PubMed).

Nagano, Yamashita, Takahashi et al.: "Siah-1 facilitates ubiquitination and degradation of synphilin-1." in: The Journal of biological chemistry, Vol. 278, Issue 51, pp. 51504-14, 2003 (PubMed).

Tanaka, Kim, Lee et al.: "Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective." in: The Journal of biological chemistry, Vol. 279, Issue 6, pp. 4625-31, 2004 (PubMed).

Lee, Tanaka, Park et al.: "Casein kinase II-mediated phosphorylation regulates alpha-synuclein/synphilin-1 interaction and inclusion body formation." in: The Journal of biological chemistry, Vol. 279, Issue 8, pp. 6834-9, 2004 (PubMed).

Krüger: "The role of synphilin-1 in synaptic function and protein degradation." in: Cell and tissue research, Vol. 318, Issue 1, pp. 195-9, 2004 (PubMed).

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