Engrailed Homeobox 2 (EN2) (C-Term) antibody

Details for Product No. ABIN359621
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Antigen
Synonyms EN2, en, en2, BB131122, En-2, RGD1561842, Gg-En-2
Epitope
C-Term
(25), (6), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(41), (17), (16), (14), (12)
Host
Rabbit
(36), (6), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(35), (18), (10), (6), (6), (5), (3), (1), (1)
Pubmed 2 references available
Quantity 0.4 mL
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Catalog No. ABIN359621
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EN2.
Specificity This antibody reacts to EN2.
Purification Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Alternative Name engrailed-2 / EN2
Background EN2 is thought to have a role in controlling development. In Drosophila, the protein plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. This protein has been implicated in the control of pattern formation during development of the central nervous system.
Alternate names: EN-2, Homeobox protein engrailed-2, Hu-En-2
Gene ID 2020, 9606
UniProt P19622
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Poole, Law, Kao et al.: "Isolation and chromosomal localization of the human En-2 gene." in: Genomics, Vol. 4, Issue 3, pp. 225-31, 1989 (PubMed).

Benayed, Gharani, Rossman et al.: "Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus." in: American journal of human genetics, Vol. 77, Issue 5, pp. 851-68, 2005 (PubMed).

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