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Details for Product No. ABIN360330

Protein Kinase D2 (PKD2) (C-Term) antibody

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Antigen
Synonyms PKD2, nPKC-D2, AI325941, RGD1308054, PRKD2
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality Polyclonal
Application
»Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN360330
Quantity 0.4 mL
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This PKC-D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of Human PKD2. Genename: PRKD2
Specificity This antibody recognizes Protein Kinase D2 (PKD2).
Purification Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PRKD2 / PKD2
Background PKD2, a member of the polycystin family, functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis. PKD2 interacts with PKD1, potentially through the C-terminal region. PKD1 requires the presence of PKD2 for stable expression. PKD2 also interacts with CD2AP. This protein is strongly expressed in ovary, fetal and adult kidney, testis, and small intestine, but is not detected in peripheral leukocytes. Defects in PKD2 are the cause of autosomal dominant polycystic kidney disease type II (ADPKD-2) which represent approximately 15% of cases of autosomal dominant polycystic kidney disease, a common autosomal dominant genetic disease affecting about 1 out 1000 individuals. ADPKD is characterized by progressive formation and enlargement of cysts in both kidneys, typically leading to end-stage renal disease in adult life. Cysts also occurs in the liver and other organs. All mutations, scattered between exons 1 and 11, result in a truncated PKD2 that lacks both the calcium-binding EF-hand domain and the two cytoplasmic domains required for the interaction of PKD2 with PKD1 and with itself. ADPKD type II is clinically milder than ADPKD type I, but it has a deleterious impact on overall life expectancy.
Alternate names: HSPC187, PKC-D2, Serine/threonine-protein kinase D2, nPKC-D2
Gene ID 25865
NCBI Accession NP_001073349
UniProt Q9BZL6
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry on Paraffin Sections: 1/50-1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) Sodium Azide as preservative.
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Background publications Hayashi, Mochizuki, Reynolds et al.: "Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2)." in: Genomics, Vol. 44, Issue 1, pp. 131-6, 1997 (PubMed).

Torra, Viribay, Tellería et al.: "Seven novel mutations of the PKD2 gene in families with autosomal dominant polycystic kidney disease." in: Kidney international, Vol. 56, Issue 1, pp. 28-33, 1999 (PubMed).

Watnick, He, Wang et al.: "Mutations of PKD1 in ADPKD2 cysts suggest a pathogenic effect of trans-heterozygous mutations." in: Nature genetics, Vol. 25, Issue 2, pp. 143-4, 2000 (PubMed).

Lehtonen, Ora, Olkkonen et al.: "In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 32888-93, 2000 (PubMed).

Stayner, Zhou: "Polycystin channels and kidney disease." in: Trends in pharmacological sciences, Vol. 22, Issue 11, pp. 543-6, 2001 (PubMed).

Alternatives for antigen "Protein Kinase D2 (PKD2)", type "Antibodies"
Hosts (37), (18)
Reactivities (55), (11), (9), (4), (4), (1), (1), (1)
Applications (49), (19), (19), (14), (13), (6), (5), (3), (1), (1)
Epitopes (7), (4), (4), (2), (2), (2), (1), (1), (1), (1)
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