Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Ser67) antibody

Details for Product No. ABIN360476
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Antigen
Synonyms NNX3, RMP, gep, gna12, gna12l, AI414047, AI504261, Galpha12
Epitope
Ser67
(14), (7), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(42), (30), (27), (25), (25), (24), (12), (1), (1)
Host
Rabbit
(43), (2)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(26), (20), (11), (7), (2), (1)
Pubmed 5 references available
Quantity 0.4 mL
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Catalog No. ABIN360476
357.50 $
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S67 of human GNA12.
Specificity This antibody reacts to GNA12.
Purification Protein A column, followed by peptide affinity purification
Alternative Name G protein subunit alpha 12 / GNA12
Background Guanine nucleotide-binding proteins (G proteins) are modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 subunits, alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Alternate names: G alpha-12, Guanine nucleotide-binding protein subunit alpha-12
Gene ID 2768, 9606
UniProt Q03113
Application Notes ELISA: 1/1,000. Western blotting: 1/50 - 1/100. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09% (w/v) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Ser67) antibody anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Ser67) antibody
Background publications Suzuki, Nakamura, Mano et al.: "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 733-8, 2003 (PubMed).

Yamaguchi, Katoh, Negishi: "N-terminal short sequences of alpha subunits of the G12 family determine selective coupling to receptors." in: The Journal of biological chemistry, Vol. 278, Issue 17, pp. 14936-9, 2003 (PubMed).

Scherer, Cheung, MacDonald et al.: "Human chromosome 7: DNA sequence and biology." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, 2003 (PubMed).

Hillier, Fulton, Fulton et al.: "The DNA sequence of human chromosome 7. ..." in: Nature, Vol. 424, Issue 6945, pp. 157-64, 2003 (PubMed).

Krakstad, Ardawatia, Aragay: "A role for Galpha12/Galpha13 in p120ctn regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 28, pp. 10314-9, 2004 (PubMed).

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