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Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1) (N-Term) antibody

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Synonyms MGC53289, GNB2L1, AL033335, GB-like, Gnb2-rs1, Rack1, p205, RACK1, H12.3, HLC-7, PIG21, rack1, wu:fb80d08, wu:fk65d12, gnb2-rs1, h12.3, hlc-7, pig21, C12-3, c12.3
(20), (14), (8), (3), (2), (2), (2), (1), (1), (1), (1)
(79), (29), (26), (6), (6), (5), (4), (3), (2), (2), (2), (1), (1), (1)
(73), (6), (4)
(3), (2), (2), (2), (2), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(60), (30), (29), (19), (6), (5), (3), (2), (2), (1)
Pubmed 5 references available
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Quantity 0.4 mL
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Availability Will be delivered in 6 to 8 Business Days
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human GNB2L1.
Isotype Ig
Specificity This antibody reacts to GNB2L1.
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name GNB2L1 / HLC7 (GNB2L1 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.Synonyms: Cell proliferation-inducing gene 21 protein, G protein beta 2 like 1, Guanine nucleotide-binding protein subunit beta-2-like 1, Human lung cancer oncogene 7 protein, PIG21, RACK1, Receptor for activated C kinase, Receptor of activated protein kinase C 1
Gene ID 10399, 9606
UniProt P63244
Application Notes ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
Supplier Images
Image no. 1 for anti-Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1) (N-Term) antibody (ABIN360524) anti-Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1) (N-Term) antibody
Image no. 2 for anti-Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1) (N-Term) antibody (ABIN360524) anti-Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 2-Like 1 (GNB2L1) (N-Term) antibody (Image 2)
Background publications Ceci, Gaviraghi, Gorrini et al.: "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly." in: Nature, Vol. 426, Issue 6966, pp. 579-84, 2003 (PubMed).

Usacheva, Tian, Sandoval et al.: "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 6, pp. 2989-94, 2003 (PubMed).

Tcherkasowa, Adam-Klages, Kruse et al.: "Interaction with factor associated with neutral sphingomyelinase activation, a WD motif-containing protein, identifies receptor for activated C-kinase 1 as a novel component of the signaling pathways of the p55 TNF receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 9, pp. 5161-70, 2002 (PubMed).

Kiely, Sant, OConnor: "RACK1 is an insulin-like growth factor 1 (IGF-1) receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22581-9, 2002 (PubMed).

Liedtke, Yun, Kyle et al.: "Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor." in: The Journal of biological chemistry, Vol. 277, Issue 25, pp. 22925-33, 2002 (PubMed).

Catalog No. ABIN360524
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