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GRAF antibody (rho GTPase Activating Protein 26) (Middle Region)

Details for Product anti-ARHGAP26 Antibody No. ABIN360552, Supplier: Login to see New
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Synonyms ARHGAP26, GRAF, GRAF1, OPHN1L, OPHN1L1, 1810044B20Rik, 2610010G17Rik, 4933432P15Rik, AI853435, mKIAA0621
Middle Region
(30), (11), (9), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(85), (23), (22), (3), (3), (1), (1)
(65), (16), (4)
This GRAF antibody is un-conjugated
(6), (6), (6), (5), (5), (5), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(56), (50), (31), (11), (5), (2)
Pubmed 4 references available
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Quantity 0.4 mL
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Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human OPHN1L.
Isotype Ig
Specificity This antibody is specific to GRAF (OPHN1L).
Purification Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
Alternative Name ARHGAP26 / OPHN1L (ARHGAP26 Antibody Abstract)
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.Synonyms: GRAF, GTPase regulator associated with focal adhesion kinase, KIAA0621, Oligophrenin-1-like protein, Rho GTPase-activating protein 26, Rho-type GTPase-activating protein 26
Gene ID 23092, 9606
UniProt Q9UNA1
Application Notes ELISA: 1/1,000. Western blotting: 1/100-1/500. Immunohistochemistry: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS with 0.09 % (W/V) Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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 image for anti-GRAF antibody (rho GTPase Activating Protein 26) (Middle Region) (ABIN360552) anti-rho GTPase Activating Protein 26 (ARHGAP26) (Middle Region) antibody
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Background publications Ramakers: "Rho proteins, mental retardation and the cellular basis of cognition." in: Trends in neurosciences, Vol. 25, Issue 4, pp. 191-9, 2002 (PubMed).

Borkhardt, Bojesen, Haas et al.: "The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5q." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 16, pp. 9168-73, 2000 (PubMed).

Billuart, Bienvenu, Ronce et al.: "Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation." in: Nature, Vol. 392, Issue 6679, pp. 923-6, 1998 (PubMed).

Callan: "The organization of genetic units in chromosomes." in: Journal of cell science, Vol. 2, Issue 1, pp. 1-7 (PubMed).

Catalog No. ABIN360552
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