Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) (AA 1019-1293) antibody

Details for Product No. ABIN361762
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Antigen
Synonyms CACNA1HB, Cav3.2, ECA6, EIG6, MNCb-1209, alpha13.2
Epitope
AA 1019-1293
Reactivity
Human, Mouse (Murine), Rat (Rattus)
Host
Mouse
Clonality (Clone)
Monoclonal ()
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
Pubmed 3 references available
Quantity 100 μg
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Immunogen Fusion protein amino acids 1019-1293 (II-III loop) of human Cav3.2
Clone S55-10
Specificity Detects ~260 kDa. No cross-reactivity against Cav1.3.
Sensitivity 1 µg/mL of SMC-303 was sufficient for detection of Cav3.2 in 10 µg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Background CaV3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (1, 2). Studies also suggest that the up-regulations of CaV3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (3).
Cellular Localization: Membrane
Gene ID 8912
NCBI Accession NP_001005407
UniProt O95180
Research Area Ion Channels, Transporters
Application Notes Recommended Dilution: WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
anti-Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) (AA 1019-1293) antibody Cav3.2 (S55-10), Human hippocampus
Background publications Khosravani, Altier, Simms et al.: "Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 9681-4, 2004 (PubMed).

General Gackiuere, Bidaux, Delcourt et al.: "CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 15, pp. 10162-73, 2008 (PubMed).

Chen, Lu, Pan et al.: "Association between genetic variation of CACNA1H and childhood absence epilepsy." in: Annals of neurology, Vol. 54, Issue 2, pp. 239-43, 2003 (PubMed).

Validation Images
Catalog No. ABIN361762
383.90 $
Plus shipping costs $45.00
Quantity
Price
100 μg
383.90 $

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