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Details for Product No. ABIN361762

Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) (AA 1019-1293) antibody

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Synonyms Cav3.2, MNCb-1209, alpha13.2, CACNA1HB, ECA6, EIG6
»Alternatives AA 1019-1293
»Alternatives Human, Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN361762
Quantity 100 µg
367.40 $   Plus shipping costs $45.00
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Immunogen Fusion protein AA 1019-1293 (II-III loop) of human Cav3.2
Clone S55-10
Isotype IgG1
Specificity Detects approx. 260 kDa.
Cross-Reactivity (Details) No cross-reactivity against Cav1.3
Sensitivity 1 µg/mL of SMC-303 was sufficient for detection of Cav3.2 in 10 µg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name CaV3.2
Background Synonyms:
CACNA1HB, Alpha1 3.2, CACNA 1H, CACNA1 HB, Cav T.2, EIG6, Voltage dependent T type calcium channel alpha 1H
Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward anandrogen-independent stage.
Gene ID 8912
NCBI Accession NP_001005407.1
UniProt O95180
Research Area Ion Channels, Transporters
Application Notes Recommended Dilution: 1-10 µg/mL (WB), 0.1-1.0 µg/mL (Perox) (IHC/ICC), 1.0-10 µg/mL (IF)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Background publications Khosravani, Altier, Simms et al.: "Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 9681-4, 2004 (PubMed).

Chen, Lu, Pan et al.: "Association between genetic variation of CACNA1H and childhood absence epilepsy." in: Annals of neurology, Vol. 54, Issue 2, pp. 239-43, 2003 (PubMed).

Gackiuere, Bidaux, Delcourt et al.: "CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 15, pp. 10162-73, 2008 (PubMed).

Alternatives for antigen "Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H)", type "Antibodies"
Hosts (18), (7)
Reactivities (25), (17), (17)
Applications (23), (14), (10), (5), (5), (3), (3), (2), (2)
Epitopes (5), (4), (4), (1)