Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) (AA 1019-1293) antibody

Details for Product No. ABIN361762
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Synonyms Cav3.2, MNCb-1209, alpha13.2, CACNA1HB, ECA6, EIG6
AA 1019-1293
(5), (5), (3), (1), (1)
Human, Rat (Rattus)
(24), (18), (16)
(20), (6)
Clonality (Clone)
Monoclonal ()
Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF)
(24), (18), (10), (6), (4), (2), (2), (2), (2), (1)
Pubmed 3 references available
Catalog no. ABIN361762
Quantity 100 µg
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Immunogen Fusion protein AA 1019-1293 (II-III loop) of human Cav3.2
Clone S55-10
Isotype IgG1
Specificity Detects approx. 260 kDa.
Cross-Reactivity (Details) No cross-reactivity against Cav1.3
Sensitivity 1 µg/mL of SMC-303 was sufficient for detection of Cav3.2 in 10 µg of HEK cell lysate expressing Cav3.2 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Purification Protein G Purified
Alternative Name CaV3.2
Background Synonyms:
CACNA1HB, Alpha1 3.2, CACNA 1H, CACNA1 HB, Cav T.2, EIG6, Voltage dependent T type calcium channel alpha 1H
Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy. Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward anandrogen-independent stage.
Gene ID 8912
NCBI Accession NP_001005407.1
UniProt O95180
Research Area Ion Channels, Transporters
Application Notes Recommended Dilution: 1-10 µg/mL (WB), 0.1-1.0 µg/mL (Perox) (IHC/ICC), 1.0-10 µg/mL (IF)
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Storage -20 °C
Supplier Images
anti-Calcium Channel, Voltage-Dependent, T Type, alpha 1H Subunit (CACNA1H) (AA 1019-1293) antibody Cav3.2 (S55-10), Human hippocampus
Background publications Khosravani, Altier, Simms et al.: "Gating effects of mutations in the Cav3.2 T-type calcium channel associated with childhood absence epilepsy." in: The Journal of biological chemistry, Vol. 279, Issue 11, pp. 9681-4, 2004 (PubMed).

General Chen, Lu, Pan et al.: "Association between genetic variation of CACNA1H and childhood absence epilepsy." in: Annals of neurology, Vol. 54, Issue 2, pp. 239-43, 2003 (PubMed).

Gackiuere, Bidaux, Delcourt et al.: "CaV3.2 T-type calcium channels are involved in calcium-dependent secretion of neuroendocrine prostate cancer cells." in: The Journal of biological chemistry, Vol. 283, Issue 15, pp. 10162-73, 2008 (PubMed).

Hosts (20), (6)
Reactivities (24), (18), (16)
Applications (24), (18), (10), (6), (4), (2), (2), (2), (2), (1)
Epitopes (5), (5), (3), (1), (1)
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