ITGB7
Reactivity: Human
ELISA, IF
Host: Mouse
Monoclonal
8D3
unconjugated
Application Notes
Flow Cytometry. (Ref.1-4)Immunohistochemistry on Frozen Sections. (Ref.3)Induction of homotypic cellular aggregation. Blockade of binding to cell adhesion molecules. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
0.5 mg/mL
Buffer
PBS containing no preservatives.
Preservative
Without preservative
Storage
-20 °C
Storage Comment
Store the antibody undiluted in (aliquots) at -20 °C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
The lymphocyte Peyer's patch adhesion molecule (LPAM-1), also known as Integrin alpha 4 beta 7 is a member of the integrin family of cell surface receptors. It is expressed primarily on mucosal lymphocytes, but is also present on NK cells and eosinophils. The alpha 4 beta 7 heterodimer mediates the binding of lymphocytes to its ligand, mucosal vascular addressin (MAdCAM1) on the high endothelial venules, thereby directing the homing of lymphocytes into Peyer's patches and intestinal lamina propria. (Ref.1-4)Synonyms: Adhesion Molecule, CD49d, ITGA4, ITGB7, Integrin alpha 4, Integrin alpha-4/beta-7, Integrin beta 7, LPAM1, Lymphocyte Peyer Patch, VLA-4