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CD16 Molecule (CD16) antibody (Biotin)

Details for Product No. ABIN371542, Supplier: Log in to see
Antigen
  • Fcgr3
  • Fcgr3a
  • CD16
  • FCGR3
  • FCGR3@
  • CD16b
  • FCG3
  • FCR-10
  • FCRIII
  • FCRIIIb
  • FcRIII
Reactivity
Human
379
46
20
13
13
9
8
6
6
4
4
4
4
2
2
2
1
Host
Mouse
388
43
28
1
Clonality (Clone)
Monoclonal ()
Conjugate
Biotin
71
60
42
17
8
8
7
7
5
5
4
4
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
386
81
58
51
41
41
35
22
17
10
9
6
2
1
1
1
1
1
1
Supplier
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Clone GRM1
Isotype IgG2a
Specificity This antibody recognizes CD16/FcgammaRIII.
Characteristics Synonyms: CD16a, CD16b, FCG3, FCGR3, IGFR3, FCGR3B, Fc-gamma RIII, FcRIII, Low affinityimmunoglobulin gamma Fc region receptor III
Alternative Name CD16 (CD16 Antibody Abstract)
Background CD16 (FcgammaRIII) serves as a low affinity IgG receptor. Human CD16 is expressed in two forms CD16a and CD16b. CD16a is a transmembrane protein of monocytes, macrophages, NK cells and a subset of T cells. CD16b is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a proadhesive phenotype. CD16 is involved in NK activation and signal transduction. (Ref.1-5)Synonyms: CD16A, FCG3, FCGR3, FCGR3A, Fc-gamma RIII, Fc-gamma RIII-alpha, Fc-gamma RIIIa, FcR-10, FcRIII, FcRIIIa, IGFR3, IgG Fc receptor III-2, Low affinity immunoglobulin gamma Fc region receptor III-A
Gene ID 2214
Research Area Stem Cells, Hematopoietic Progenitors, Hematopoietic Stem Cells, CD Antigens, Surface Receptors of Immune Cells
Pathways
Application Notes Flow Cytometry: 10 μL/10^6 cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or in (aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Takai, Li, Sylvestre et al.: "FcR gamma chain deletion results in pleiotrophic effector cell defects." in: Cell, Vol. 76, Issue 3, pp. 519-29, 1994 (PubMed).

Ravetch, Perussia: "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions." in: The Journal of experimental medicine, Vol. 170, Issue 2, pp. 481-97, 1989 (PubMed).