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Details for Product No. ABIN371609

Bcl-2-Like 1 antibody (Biotin)

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»Alternatives Human, Mouse (Murine), Rat (Rattus)
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
»Alternatives Biotin
»Alternatives Flow Cytometry (FACS)
Pubmed 15 references available
Catalog no. ABIN371609
Quantity 0.1 mg
412.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Recombinant Bcl-xS.
Clone 7B2-5
Isotype IgG3
Characteristics Synonyms: Bcl2-L-1, BCL2L1, BCL2L, BCLX, Bcl-x, bcl-xL, bcl-xS, Bcl-2-like protein 1
Background Apoptosis, or programmed cell death, is a well-documented phenomenon in many cellularsystems. (Ref. 1) It plays a key role in tissue and organ development as well as in adulttissues during cell turnover. Apoptosis can be induced by a variety of internal and externalstimuli including growth factor deprivation, cytokine treatment, antigen-receptorengagement, cell-cell interactions, irradiation and glucocorticoid treatment. (Ref. 2) Bcl-2and one of its homologues, Bcl-xL, protect cells from apoptosis (Ref. 3,4) while otherhomologues of Bcl-2 such as Bax, Bad and Bak have been shown to enhance apoptosis. (Ref. 5-8) Bcl-xL has been shown to block apoptosis which is induced by a variety of stimuliand, under certain conditions, offers greater protection against apoptosis than Bcl-2. (Ref. 9-13)In contrast, Bad and Bax inhibit the protective functions of Bcl-xL and Bcl-2, respectively. Although heterodimerization between Bcl-xL/Bad and Bcl-2/Bax was originally thought tobe essential for the differential anti-apoptotic activity of Bcl-xL and Bcl-2. (Ref. 5,14)Other results suggest that the formation of heterodimers may not be necessary for thisdeath-repressing activity. (Ref. 15,16)
UniProt Q07817
Research Area Cancer
Application Notes Flow Cytometry: < / = 3 µg/10e6 cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.1 mg/mL
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Cohen: "Programmed cell death in the immune system." in: Advances in immunology, Vol. 50, pp. 55-85, 1991 (PubMed).

Gottschalk, Boise, Thompson et al.: "Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 15, pp. 7350-4, 1994 (PubMed).

Cory: "Regulation of lymphocyte survival by the bcl-2 gene family." in: Annual review of immunology, Vol. 13, pp. 513-43, 1995 (PubMed).

Farrow, White, Martinou et al.: "Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K." in: Nature, Vol. 374, Issue 6524, pp. 731-3, 1995 (PubMed).

Chittenden, Harrington, OConnor et al.: "Induction of apoptosis by the Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 733-6, 1995 (PubMed).

Kiefer, Brauer, Powers et al.: "Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak." in: Nature, Vol. 374, Issue 6524, pp. 736-9, 1995 (PubMed).

Shimizu, Eguchi, Kosaka et al.: "Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL." in: Nature, Vol. 374, Issue 6525, pp. 811-3, 1995 (PubMed).

González-García, García, Ding et al.: "bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 10, pp. 4304-8, 1995 (PubMed).

Dole, Jasty, Cooper et al.: "Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis." in: Cancer research, Vol. 55, Issue 12, pp. 2576-82, 1995 (PubMed).

Yin, Oltvai, Korsmeyer: "BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax." in: Nature, Vol. 369, Issue 6478, pp. 321-3, 1994 (PubMed).

Boise, González-García, Postema et al.: "bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death." in: Cell, Vol. 74, Issue 4, pp. 597-608, 1993 (PubMed).

Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).

Cheng, Levine, Boise et al.: "Bax-independent inhibition of apoptosis by Bcl-XL." in: Nature, Vol. 379, Issue 6565, pp. 554-6, 1996 (PubMed).

Nuñez, Clarke: "The Bcl-2 family of proteins: regulators of cell death and survival." in: Trends in cell biology, Vol. 4, Issue 11, pp. 399-403, 2004 (PubMed).

Gottschalk, Boise, Oltvai et al.: "The ability of Bcl-x(L) and Bcl-2 to prevent apoptosis can be differentially regulated." in: Cell death and differentiation, Vol. 3, Issue 1, pp. 113-8, 2006 (PubMed).

Alternatives for antigen "Bcl-2-Like 1", type "Antibodies"
Hosts (28), (10), (1)
Reactivities (39), (30), (23), (3), (2), (1)
Applications (32), (26), (6), (6), (5), (4), (2), (2), (2)
Conjugates (1), (1)
Epitopes (6), (4), (3), (2), (1), (1), (1), (1), (1)