SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody

Details for Product No. ABIN374106
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Antigen
Synonyms im:5777505, wu:fa08f03, wu:fb13e12, MGC79086, sh3glb1, wu:fc55h11, wu:fj98d09, AA409932, AI314629, AU015566, Bif-1, mKIAA0491, PPP1R70, dJ612B15.2
Epitope
C-Term
(15), (7), (6), (6), (4), (3), (3), (1), (1), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(47), (13), (7), (1)
Host
Goat
(37), (9), (3), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(42), (23), (16), (11), (7), (6), (4), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374106
357.50 $
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Immunogen Peptide from the C Terminus of the protein sequence according to NP_057093.1 Genename: SH3GLB1
Sequence C-QKGKVPITYL ELLN
Specificity This antibody detects BIF1 / Endophilin-B1 at C-term.
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name Endophilin-B1
Background Bif is a member of the endophilin B protein family and may be an important component of the mitochondrial pathway for apoptosis, as a novel Bax/Bak activator. The loss of this proapoptotic molecule may contribute to tumorigenesis. Endophilins have been proposed to play roles in membrane trafficking reactions through interactions with endocytic protein via physical or chemical modifications of the membrane bilayer, particularly in presynaptic vesicle trafficking at nerve terminals. Bif (Endophilin B1), like endophilins A, binds to palmitoyl CoA and exhibits lysophosphatidic acid acyl transferase activity.
Alternate names: BIF1, Bax-interacting factor 1, Bif-1, KIAA0491, SH3 domain-containing GRB2-like protein B1, SH3GLB1
Gene ID 51100
NCBI Accession NP_057093
UniProt Q9Y371
Application Notes Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.3-1.0 µg/ml. Approx 38kDa band observed in lysates of Human T cell lineJurkat and in Human Lung and Placenta (calculated MW of 40.8kDa according toNP_057093.1). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Expiry Date 12 months
Supplier Images
anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody anti-SH3-Domain GRB2-Like Endophilin B1 (SH3GLB1) (C-Term) antibody
Background publications Takahashi, Karbowski, Yamaguchi et al.: "Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis." in: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9369-82, 2005 (PubMed).

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