Forkhead Box P3 (FOXP3) (C-Term) antibody

Details for Product No. ABIN374156
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Antigen
Synonyms foxp3, FOXP3, AIID, DIETER, IPEX, PIDX, XPID, JM2, scurfin, sf, RGD1562112
Epitope
C-Term
(66), (18), (7), (7), (7), (5), (5), (5), (5), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Human, Pig (Porcine)
(187), (121), (46), (7), (2), (2), (2)
Host
Goat
(152), (59), (43), (13)
Clonality
Polyclonal
Conjugate
Un-conjugated
(19), (16), (15), (9), (7), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(174), (91), (72), (57), (38), (10), (10), (9), (9), (8), (8), (7), (7), (4), (3), (2)
Pubmed 13 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN374156
368.50 $
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Immunogen Peptide from C-Terminus of the protein sequence according to NP_054728.2, NP_001107849.1. Genename: FOXP3
Sequence SQRPSRCSNP TPGP
Specificity This antibody is expected to recognize both reported isoforms (NP_054728.2 and NP_001107849.1).
Cross-Reactivity (Details) Species reactivity (expected):Canine (Dog) and Pig.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name FOXP3
Background FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin
Gene ID 50943
NCBI Accession NP_054728
UniProt Q9BZS1
Research Area Immunology, Adaptive Immunity, Transcription Factors
Application Notes Peptide ELISA: Limit Dilution: 1/16000. Immunohistochemistry: 0.3-1 μg/mL. In paraffin embedded Human Tonsil, stains nuclei ofsome cells in the interfollicular area.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Forkhead Box P3 (FOXP3) (C-Term) antibody anti-Forkhead Box P3 (FOXP3) (C-Term) antibody
anti-Forkhead Box P3 (FOXP3) (C-Term) antibody (2) anti-Forkhead Box P3 (FOXP3) (C-Term) antibody (Image 2)
Background publications Stahl, Fauti, Ullrich et al.: "miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression." in: PLoS ONE, Vol. 4, Issue 9, pp. e7158, 2009 (PubMed).

Chaumont, Wipff: "Ion aggregation in concentrated aqueous and methanol solutions of polyoxometallates Keggin anions: the effect of counterions investigated by molecular dynamics simulations." in: Physical chemistry chemical physics : PCCP, Vol. 10, Issue 46, pp. 6940-53, 2008 (PubMed).

Mansour, Homs, Desvaux et al.: "Intragraft levels of Foxp3 mRNA predict progression in renal transplants with borderline change." in: Journal of the American Society of Nephrology : JASN, Vol. 19, Issue 12, pp. 2277-81, 2008 (PubMed).

Baumforth, Birgersdotter, Reynolds et al.: "Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates Up-regulation of CCL20 and the migration of regulatory T cells." in: The American journal of pathology, Vol. 173, Issue 1, pp. 195-204, 2008 (PubMed).

Radulovic, Jacobson, Durham et al.: "Grass pollen immunotherapy induces Foxp3-expressing CD4+ CD25+ cells in the nasal mucosa." in: The Journal of allergy and clinical immunology, Vol. 121, Issue 6, pp. 1467-72, 1472.e1, 2008 (PubMed).

Banham, Brown, Lyne et al.: "Is FOXP3 expressed in cutaneous T-cell lymphomas?" in: European journal of haematology, Vol. 80, Issue 1, pp. 90-1, 2008 (PubMed).

Ward, Hall, Cairns et al.: "Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia." in: Blood, Vol. 111, Issue 2, pp. 680-7, 2008 (PubMed).

Nakamura, Shima, Saeki et al.: "Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer." in: Cancer science, Vol. 98, Issue 6, pp. 874-81, 2007 (PubMed).

Soler, Chapman, Poisson et al.: "CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 10, pp. 6940-51, 2006 (PubMed).

Kitamura, Torigoe, Honma et al.: "Effect of human leukocyte antigen class I expression of tumor cells on outcome of intravesical instillation of bacillus calmette-guerin immunotherapy for bladder cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 12, Issue 15, pp. 4641-4, 2006 (PubMed).

Appay, Jandus, Voelter et al.: "New generation vaccine induces effective melanoma-specific CD8+ T cells in the circulation but not in the tumor site." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 3, pp. 1670-8, 2006 (PubMed).

Epple, Loddenkemper, Kunkel et al.: "Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART." in: Blood, Vol. 108, Issue 9, pp. 3072-8, 2006 (PubMed).

Michaëlsson, Mold, McCune et al.: "Regulation of T cell responses in the developing human fetus." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 10, pp. 5741-8, 2006 (PubMed).

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