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Details for Product No. ABIN374181

Dickkopf 2 Homolog (Xenopus Laevis) (DKK2) (C-Term) antibody

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Synonyms DKK-2, Dkk4
»Alternatives C-Term
»Alternatives Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374181
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence ATYSSKARLHVCQKI, from the C Terminus of the protein sequence Genename: DKK2
Specificity This antibody detects Dickkopf-2 at C-term. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine, Bovine.
Purification Affinity chromatography
Alternative Name Dickkopf-2 (DKK2)
Background Analysis of individual DKK domains and chimeric DKKs shows that the carboxy-terminal domains of both DKK1 and DKK2 associate with LRP6 and are necessary and sufficient for Wnt8 inhibition. Xenopus Dickkopf 1 (DKK1) was initially discovered as a Wnt antagonist that plays an important role in head formation. By far, four members of DKK have been identified in mammals. Each DKK molecule contains two conserved cysteine-rich domains. Recent studies showed that the second Cys-rich domains of DKK1 and DKK2 inhibited Wnt3a-activated signaling, whereas the first Cys-rich domains had no effects. In addition, the second Cys-rich domain of DKK2, but not that of DKK1, was able to activate the canonical pathway in the presence of LRP6, and this LRP-dependent signaling does not require Dvl.
Alternate names: Dickkopf-related protein 2, Dkk-2
Gene ID 27123
NCBI Accession NP_055236.1
UniProt Q9UBU2
Application Notes Peptide ELISA: 1/8000. Western blot: 1 - 3 µg/ml. Approx 28kDa band observed in Human Heart lysate (calculatedMW of 28.5kDa according to NP_055236). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Krupnik, Sharp, Jiang et al.: "Functional and structural diversity of the human Dickkopf gene family." in: Gene, Vol. 238, Issue 2, pp. 301-13, 1999 (PubMed).

Alternatives for antigen "Dickkopf 2 Homolog (Xenopus Laevis) (DKK2)", type "Antibodies"
Hosts (40), (7)
Reactivities (41), (23), (16), (12), (12), (12), (1)
Applications (35), (17), (12), (10), (7), (2), (2), (2)
Conjugates (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (4), (2), (2), (2), (1), (1), (1), (1)