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Death-Associated Protein 3 (DAP3) (C-Term) antibody

Details for Product No. ABIN374210
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Antigen
Synonyms DAP-3, MRP-S29, MRPS29, bMRP-10, 4921514D13Rik, BC058433, DAP3, Prpl8, Sapap3
Epitope
C-Term
(5), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(43), (18), (13)
Host
Goat
(34), (6), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(32), (14), (9), (6), (4), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN374210
357.50 $
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Immunogen Peptide from C Terminus of the protein sequence according to NP_387506.1, NP_004623.1 Genename: DAP3
Sequence NPSLLERHCAYL
Specificity This antibody detects DAP3 / MRPS29 at C-term. Species Reactivity: Tested: Human.
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name DAP3 / MRPS29
Background Death Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon- gamma and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions.
Alternate names: 28S ribosomal protein S29 mitochondrial, DAP-3, Death-associated protein 3, Ionizing radiation resistance conferring protein, MRP-S29
Gene ID 7818
NCBI Accession NP_387506.1
UniProt P51398
Application Notes Peptide ELISA: 1/16000. Western blot: 1 - 3 µg/ml. Approx 40-45kDa band seen in HeLa lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Death-Associated Protein 3 (DAP3) (C-Term) antibody anti-Death-Associated Protein 3 (DAP3) (C-Term) antibody
anti-Death-Associated Protein 3 (DAP3) (C-Term) antibody (2) anti-Death-Associated Protein 3 (DAP3) (C-Term) antibody (Image 2)
Background publications Kissil, Deiss, Bayewitch et al.: "Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death." in: The Journal of biological chemistry, Vol. 270, Issue 46, pp. 27932-6, 1996 (PubMed).

Validation Images
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