Heat Shock 22kDa Protein 8 (HSPB8) (C-Term) antibody

Details for Product No. ABIN374275
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Antigen
Synonyms MGC64408, fc09c11, wu:fc04b04, wu:fc09c11, zgc:64202, CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22, AU018630, AW413033, Cryac, D5Ucla4, H11K, HSP20-like, Hsp22
Epitope
C-Term
(7), (6), (5), (3), (3), (2), (1), (1), (1)
Reactivity
Human
(86), (26), (23), (13), (13), (12)
Host
Goat
(41), (38), (7)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
(72), (42), (38), (25), (11), (10), (8), (5), (4), (4), (2), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374275
368.50 $
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Immunogen Peptide from C Terminus of the protein sequence according to NP_055180.1 Genename: HSPB8
Sequence NELPQDSQEV TCT
Specificity This antibody detects Heat shock protein beta-8 (HSPB8) at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name HSPB8 / HSP22
Background Hsp22 (HSPB8) is a 196-amino acid protein that contains a central portion homologous to a highly conserved HSP-alpha crystallin domain common to all the small heat shock protein (HSP20) family members. Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. The highest abundance of Hsp22 is in skeletal muscle, heart, and placenta. Mutations in the HSPB8 gene are associated with the inherited peripheral neuropathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L).Synonyms: Alpha-crystallin C chain, CRYAC, E2-induced gene 1 protein, E2IG1, Heat shock protein beta-8, Protein kinase H11, Small stress protein-like protein HSP22
Gene ID 26353
NCBI Accession NP_055180
UniProt Q9UJY1
Application Notes Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.5-1 μg/mL. Approx 20-25 kDa band seen in human skeletal muscle lysate[Predicted MW of approx.25 kDa according to NP_055180].
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Supplier Images
anti-Heat Shock 22kDa Protein 8 (HSPB8) (C-Term) antibody anti-Heat Shock 22kDa Protein 8 (HSPB8) (C-Term) antibody
Background publications Benndorf, Sun, Gilmont et al.: "HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27)." in: The Journal of biological chemistry, Vol. 276, Issue 29, pp. 26753-61, 2001 (PubMed).

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