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Details for Product No. ABIN374424

PITPNM Family Member 3 (PITPNM3) (C-Term) antibody

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Antigen
Synonyms ACKR6, CORD5, NIR1, RDGBA3, A330068P14Rik, AI848332, Ackr6, Gm880
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Dog (Canine), Human, Mouse (Murine)
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374424
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide from C Terminus of the protein sequence according to NP_112497.2, NP_001159438.1. Genename: PITPNM3
Sequence C-SWARGPPKFESVP
Specificity This antibody detects NIR1 at C-term. Species Reactivity: Tested: Human Expected from sequence similarity: Mouse, Dog
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name PITPNM3
Background This gene encodes a member of a family of membrane-associated phosphatidylinositol transfer domain-containing proteins. The calcium-binding protein has phosphatidylinositol (PI) transfer activity and interacts with the protein tyrosine kinase PTK2B (also known as PYK2). The protein is homologous to a Drosophila protein that is implicated in the visual transduction pathway in flies. Mutations in this gene result in autosomal dominant cone dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Alternate names: Membrane-associated phosphatidylinositol transfer protein 3, NIR-1, NIR1, PITPNM 3, Phosphatidylinositol transfer protein, Pyk2 N-terminal domain-interacting receptor 1, membrane-associated 3
Gene ID 83394
NCBI Accession NP_112497.2
UniProt Q9BZ71
Application Notes Peptide ELISA: Limit dilution 1: 16000. Western blot: Preliminary experiments gave an approx 50kDa band in Human Heart lysatesafter 0.1 µg/ml antibody staining. The 50kDa band was successfully blocked by incubationwith the immunizing peptide. Immunohistochemistry: 5-10 µg/ml. In paraffin embeddedHuman Cerebral Cortex shows strong staining of cytoplasm in several neuronal cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Lev, Hernandez, Martinez et al.: "Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein." in: Molecular and cellular biology, Vol. 19, Issue 3, pp. 2278-88, 1999 (PubMed).

Alternatives for antigen "PITPNM Family Member 3 (PITPNM3)", type "Antibodies"
Hosts (17), (7)
Reactivities (22), (13), (12), (12), (12), (1)
Applications (10), (10), (8), (7), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (1), (1)
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