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Pirin (PIR) (N-Term) antibody

Details for Product No. ABIN374451, Supplier: Login to see
Antigen
  • 2310042L19Rik
  • Pirnl
  • zgc:92778
  • ATPIRIN1
  • PRN1
  • pirin
  • xpir
Epitope
N-Term
14
6
5
3
2
1
1
1
Reactivity
Human, Mouse (Murine)
47
9
7
4
3
1
1
Host
Goat
18
17
10
2
Clonality
Polyclonal
Conjugate
Un-conjugated
1
1
1
1
1
1
Application
Western Blotting (WB)
43
25
8
7
4
3
2
1
1
1
1
Supplier
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Immunogen Peptide from the N Terminus of the protein sequence according to NP_003653.
Sequence GSSKKVTLSV LSREC
Cross-Reactivity (Details) Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name Pirin / PIR (PIR Antibody Abstract)
Background The pirin gene encodes a member of the cupin superfamily. The protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor, as well as B cell lymphoma 3-encoded oncoprotein, suggest that the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication.Synonyms: 3-dioxygenase PIR, Probable quercetin 2, Probable quercetinase
Gene ID 8544
NCBI Accession NP_001018119
UniProt O00625
Pathways
Application Notes Peptide ELISA: 1/128,000. Western Blot: 0.3-1.0 μg/mL. Detects a band of Approx 30-35 kDa in Human Heart lysate. (Predicted Molecular Weight: 32.5 kDa).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.
Supplier Images
 image for anti-Pirin (PIR) (N-Term) antibody (ABIN374451) anti-Pirin (PIR) (N-Term) antibody
 image for anti-Pirin (PIR) (N-Term) antibody (ABIN374451) anti-Pirin (PIR) (N-Term) antibody (Image 2)
Background publications Parada, Reis, Pinto et al.: "Chemopreventive Efficacy of Atorvastatin against Nitrosamine-Induced Rat Bladder Cancer: Antioxidant, Anti-Proliferative and Anti-Inflammatory Properties." in: International journal of molecular sciences, Vol. 13, Issue 7, pp. 8482-99, 2012 (PubMed).

Wendler, Kremmer, Förster et al.: "Identification of pirin, a novel highly conserved nuclear protein." in: The Journal of biological chemistry, Vol. 272, Issue 13, pp. 8482-9, 1997 (PubMed).