Parvalbumin (PVALB) (C-Term) antibody

Details for Product No. ABIN374572
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Antigen
Synonyms pvalb1, pvalb, zgc:92782, MGC107903, zgc:56217, zgc:77798, D22S749, PALB1, Pva, PV, Parv, ATH, PVALB, thymic
Epitope
C-Term
(8), (2), (1), (1)
Reactivity
Human, Rat (Rattus)
(37), (30), (26), (12), (12), (12), (2)
Host
Goat
(31), (7), (6), (2), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(28), (15), (11), (11), (10), (7), (3), (2), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374572
357.50 $
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  • +1 404 474 4654
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Immunogen Peptide with sequence from the C Terminus of the protein sequence according to NP_002845.1.
Sequence C-GVDEFSTLVA ES
Specificity This antibody recognizes Parvalbumin.
Cross-Reactivity (Details) Species reactivity (tested):Human, Rat.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Alternative Name Parvalbumin alpha / PVALB
Background Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
Gene ID 5816
NCBI Accession NP_002845
UniProt P20472
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1-0.3 μg/mL. Approx 12 kDa band observed in Human Brain lysates (calculated MW of 12.2 kDa accordingto NP_002845.1). Approx 10-12 kDa band observed in rat skeletal muscle and in rat heart cells transfectedwith human PVALB, but not in untransfected rat heart cells. (1)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Parvalbumin (PVALB) (C-Term) antibody anti-Parvalbumin (PVALB) (C-Term) antibody
anti-Parvalbumin (PVALB) (C-Term) antibody (2) anti-Parvalbumin (PVALB) (C-Term) antibody (Image 2)
anti-Parvalbumin (PVALB) (C-Term) antibody (3) anti-Parvalbumin (PVALB) (C-Term) antibody (Image 3)
Background publications Hashimoto, Bergen, Nguyen et al.: "Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 2, pp. 372-83, 2005 (PubMed).

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