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Complement Factor H antibody (CFH) (Internal Region)

Details for Product anti-CFH Antibody No. ABIN374588, Supplier: Login to see New
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Synonyms CFH, im:7147412, si:ch211-207o17.2, Mud-1, NOM, Sas-1, Sas1, AHUS1, AMBP1, ARMD4, ARMS1, CFHL3, FH, FHL1, HF, HF1, HF2, HUS, Fh, fH
Internal Region
(25), (19), (18), (13), (10), (6), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
(213), (31), (25), (3), (3), (2), (2), (1), (1)
(99), (74), (31), (28), (2), (1)
This Complement Factor H antibody is un-conjugated
(17), (12), (5), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Western Blotting (WB)
(148), (131), (44), (43), (32), (22), (22), (20), (16), (14), (12), (9), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-HLVPDRKKDQYK, from the internal region of the protein sequence
Specificity This antibody is expected to recognize isoform a of Complement factor H (CFH) only.
Purification Affinity chromatography
Background The complement Factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations leading to changes in this protein have been linked with HUS (hemolytic-uremic syndrome) and chronic hypocomplementemic nephropathy. Factor H is mainly synthesised in the liver but also in macrophages and endothelium. It is primarily aplasma glycoprotein but is also found in platelets and there is a membrane bound form on some leukocytes. Consisting of a single polypeptide, the major form of Factor H has a molecular weight of 155 kDa. There are two truncated forms, a non-glycosylated 49 kDa form and a glycosylated 39-43 kDaform. Plasma concentrations are in the range 200-600 mg/L for the 155 kDa form and 1-5 mg/L for thetruncated forms. Factor H is a major regulatory protein of the complement system. By binding to C3b it either displacesor prevents the binding of Bb (activated Factor B). When bound to Factor H, C3b is susceptible tocleavage by Factor 1 to yield iC3b. Factor H is released or modified following this cleavage. The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated.Synonyms: CFH, H factor 1, HF, HF1, HF2
Gene ID 3075
NCBI Accession NP_000177
UniProt P08603
Research Area Coagulation, Complement Factors
Pathways Complement System
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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Image no. 1 for anti-Complement Factor H antibody (CFH) (Internal Region) (ABIN374588) anti-Complement Factor H (CFH) (Internal Region) antibody
Background publications Klein, Zeiss, Chew et al.: "Complement factor H polymorphism in age-related macular degeneration." in: Science (New York, N.Y.), Vol. 308, Issue 5720, pp. 385-9, 2005 (PubMed).

Catalog No. ABIN374588
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