Cannabinoid Receptor 1 (CNR1) (Internal Region) antibody

Details for Product No. ABIN374611
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Antigen
Synonyms CNR1, LOC540382, CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, SKR6R, cnr1-A
Epitope
Internal Region
(12), (11), (9), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Dog (Canine), Cat (Feline), Human, Mouse (Murine), Rat (Rattus)
(83), (42), (36), (14), (13), (13), (13), (5), (1), (1), (1), (1), (1), (1)
Host
Goat
(73), (9), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(69), (39), (22), (14), (13), (11), (10), (5), (3), (1), (1), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN374611
357.50 $
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Immunogen Peptide with sequence C-HTSEDGKVQVTRPDQ, from the internal region of the protein sequence
Specificity This antibody reacts to Cannabinoid receptor 1.
Cross-Reactivity (Details) Species reactivity (expected):Rat, Canine.
Species reactivity (tested):Human, Mouse.
Purification Affinity chromatography
Alternative Name Cannabinoid Receptor 1
Background Cannabinoid Receptor 1 is one of two main cannabinoid receptors which are G-protein-coupled receptors inhibiting adenylate cyclase activity. The CB(1) receptor is densely distributed in areas of the brain related to motor control, cognition, emotional responses, motivated behaviour and homeostasis. Cannabinoid receptors have a complex molecular architecture that allows a single receptor to recognize multiple classes of compounds and produce an array of distinct downstream effects. Recent pharmacological advances have led to the synthesis of cannabinoid receptor agonists and antagonists. This has helped in the development of new strategies for the treatment of pain, obesity, neurological diseases including multiple sclerosis, emotional disturbances such as anxiety and other psychiatric disorders including drug and alcohol addiction.Synonyms: CANN6, CB-R, CB1, CNR, CNR1
Gene ID 1268, 9606
UniProt P21554
Research Area Receptors
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibody anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibody
anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibody (2) anti-Cannabinoid Receptor 1 (CNR1) (Internal Region) antibody (Image 2)
Background publications Ledent, Valverde, Cossu et al.: "Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice." in: Science (New York, N.Y.), Vol. 283, Issue 5400, pp. 401-4, 1999 (PubMed).

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