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Details for Product No. ABIN374611

Cannabinoid Receptor 1 (CNR1) (Internal Region) antibody

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Synonyms CB1, CNR, CB-R, CB1A, CB1R, CANN6, CB1K5, SKR6R, CNR1, LOC540382
»Alternatives Internal Region
»Alternatives Dog (Canine), Cat (Feline), Human, Mouse (Murine), Rat (Rattus)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374611
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-HTSEDGKVQVTRPDQ, from the internal region of the protein sequence
Specificity This antibody reacts to Cannabinoid receptor 1. Species Reactivity: Tested: Human, Mouse. Expected from sequence similarity: Rat, Canine.
Purification Affinity chromatography
Alternative Name Cannabinoid receptor 1
Background Cannabinoid Receptor 1 is one of two main cannabinoid receptors which are G-protein- coupled receptors inhibiting adenylate cyclase activity. The CB(1) receptor is densely distributed in areas of the brain related to motor control, cognition, emotional responses, motivated behaviour and homeostasis. Cannabinoid receptors have a complex molecular architecture that allows a single receptor to recognize multiple classes of compounds and produce an array of distinct downstream effects. Recent pharmacological advances have led to the synthesis of cannabinoid receptor agonists and antagonists. This has helped in the development of new strategies for the treatment of pain, obesity, neurological diseases including multiple sclerosis, emotional disturbances such as anxiety and other psychiatric disorders including drug and alcohol addiction.
Alternate names: CANN6, CB-R, CB1, CNR, CNR1
Gene ID 1268
NCBI Accession 9606
UniProt P21554
Research Area Receptors
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Ledent, Valverde, Cossu et al.: "Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice." in: Science (New York, N.Y.), Vol. 283, Issue 5400, pp. 401-4, 1999 (PubMed).

Alternatives for antigen "Cannabinoid Receptor 1 (CNR1)", type "Antibodies"
Hosts (65), (9), (7)
Reactivities (76), (42), (36), (14), (12), (12), (12), (4), (1), (1), (1), (1)
Applications (60), (32), (25), (14), (12), (10), (10), (5), (1), (1), (1), (1), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (7), (6), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)