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Cannabinoid Receptor 2 (CNR2) (C-Term) antibody

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Synonyms CNR2, CB2, cb2a, cb2b, CB-2, CX5, CB2C, CNR2C, CB2-R
(42), (13), (12), (12), (10), (8), (5), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(117), (19), (18), (1), (1)
(105), (15), (4)
(5), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(78), (57), (33), (30), (18), (11), (8), (6), (2), (1), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-TETEADGKITPWPD, from the C Terminus of the protein sequence
Specificity This antibody reacts to Cannabinoid receptor 2.
Purification Affinity chromatography
Alternative Name Cannabinoid Receptor 2 (CNR2 Antibody Abstract)
Background The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.Synonyms: CB-2, CB2, CNR2, CX5, hCB2
Gene ID 1269, 9606
UniProt P34972
Research Area Receptors
Application Notes Peptide ELISA: 1/16000. Western Blot: 2 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Van Sickle, Duncan, Kingsley et al.: "Identification and functional characterization of brainstem cannabinoid CB2 receptors." in: Science (New York, N.Y.), Vol. 310, Issue 5746, pp. 329-32, 2005 (PubMed).

Catalog No. ABIN374612
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