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Cannabinoid Receptor 2 (CNR2) (C-Term) antibody

Details for Product No. ABIN374612, Supplier: Login to see
Antigen
  • CNR2
  • CB2
  • cb2a
  • cb2b
  • CB-2
  • CX5
  • CB2C
  • CNR2C
  • CB2-R
Epitope
C-Term
42
13
12
12
10
8
5
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
117
19
18
1
1
Host
Goat
105
15
4
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
4
3
3
3
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
78
57
33
30
18
11
8
6
2
1
1
Supplier
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Immunogen Peptide with sequence C-TETEADGKITPWPD, from the C Terminus of the protein sequence
Specificity This antibody reacts to Cannabinoid receptor 2.
Purification Affinity chromatography
Alternative Name Cannabinoid Receptor 2 (CNR2 Antibody Abstract)
Background The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina.Synonyms: CB-2, CB2, CNR2, CX5, hCB2
Gene ID 1269, 9606
UniProt P34972
Research Area Receptors
Pathways
Application Notes Peptide ELISA: 1/16000. Western Blot: 2 - 3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Van Sickle, Duncan, Kingsley et al.: "Identification and functional characterization of brainstem cannabinoid CB2 receptors." in: Science (New York, N.Y.), Vol. 310, Issue 5746, pp. 329-32, 2005 (PubMed).