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Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) (Internal Region) antibody

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Synonyms Cyp1, PPIA-2, fa93g09, ppia, wu:fa93g09, wu:fb05e11, wu:fb13h02, wu:fb15a05, MGC75715, CypA, PPIA, Cypa, 2700098C05, Cphn, CyP-18, CYPA, CYPH, CYCA, CyP-A, MT-ND1, MTND1, NADH1, ND1, cypA
Internal Region
(21), (17), (13), (11), (11), (6), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
(124), (57), (54), (9), (8), (6), (5), (2), (2), (1), (1)
(128), (17), (12), (1)
(19), (15), (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(109), (80), (34), (19), (12), (11), (6), (5), (3), (2), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence from the internal region of the protein sequence according to NP_066953.1. Genename: PPIA
Specificity This antibody is expected to recognise Cyclophilin A. This product is expected to recognise PPIAL (NP_001008741.1, GeneID: 388817) which is identical to PPIA (NP_066953.1).
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine, Porcine, Bovine.
Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name Cyclophilin A (PPIA Antibody Abstract)
Background Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs) and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins. Within the cyclophilin family, there are several different proteins which show a high degree of homology including CyPA, CyPB and CyPC. CyPA, also termed CyP-18, is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.Synonyms: CYPA, Cyclophilin-A, Cyclosporin A-binding protein, EC=, PPIA, PPIase A, Peptidyl-prolyl cis-trans isomerase A, Rotamase A
Gene ID 5478
NCBI Accession NP_066953
UniProt P62937
Research Area Signaling
Application Notes Peptide ELISA: Limit Dilution: 1/8000. Western blot: 0.1-0.3 μg/mL. Approx 18 kDa band observed in Human Lymph Node lysates(calculated MW 18.8 kDa according to NP_066953.1).
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) (Internal Region) antibody (ABIN374639) anti-Peptidylprolyl Isomerase A (Cyclophilin A) (PPIA) (Internal Region) antibody
Background publications Berthoux, Sebastian, Sokolskaja et al.: "Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 41, pp. 14849-53, 2005 (PubMed).

Catalog No. ABIN374639
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