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Details for Product No. ABIN374653

DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A) (C-Term) antibody

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Synonyms HSA275986, Nbla00360, SMAD4IP1, SMIF, Mitc1, AU019772, D14Ertd817e, 1110066A22Rik, 4930568L04Rik, RGD1561298, mitc1, smad4ip1, smif, DCP1A
»Alternatives C-Term
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374653
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence C-QVLTKNKDNHN, from the C Terminus of the protein sequence
Specificity This antibody reacts to DCP1A. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat.
Purification Affinity chromatography
Alternative Name DCP1A
Background Dcp1a is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1. Dcp1a binds DCP1B, DCP2, RENT1 and SMAD4 and forms part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1.
Alternate names: SMIF, Smad4-interacting transcriptional co-activator, Transcription factor SMIF, mRNA- decapping enzyme 1A
Gene ID 55802
NCBI Accession 9606
UniProt Q9NPI6
Application Notes Peptide ELISA: 1/4000. Western Blot: 1 - 3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Cougot, Babajko, Séraphin: "Cytoplasmic foci are sites of mRNA decay in human cells." in: The Journal of cell biology, Vol. 165, Issue 1, pp. 31-40, 2004 (PubMed).

Alternatives for antigen "DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) (DCP1A)", type "Antibodies"
Hosts (34), (12), (5)
Reactivities (49), (26), (15), (14), (14), (12), (1), (1), (1)
Applications (39), (26), (10), (4), (3), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (5), (3), (2), (2), (1), (1), (1)