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Details for Product No. ABIN374691

Myosin IXB (MYO9B) (Internal Region) antibody

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Antigen
Synonyms MYR5, CELIAC4, MYO9B, fb53f01, wu:fb53f01, wu:fc47c07, si:dkeyp-66d1.8
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Human
Host
Clonality Polyclonal
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374691
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide with sequence C-KNDFEPVKQSKAQ, from the internal region of the protein sequence
Specificity This antibody reacts to Myosin IXB.
Purification Affinity chromatography
Alternative Name Myo9b
Background Myosin IX belongs to the family of unconventional myosins, distinct from the classical myosins I and myosins II. Myosin IX, thought to be involved in signal transduction and leukocyte differentiation, includes several isoforms. The rat isoforms are myosin IX/Myr5 (230 kDa) and Myr7 (300 kDa), and the human isoforms are myosin IXa (MYO9A) and myosin IXb (MYO9B). The isoforms of myosin IX have similar overall domain structure and are expressed in many tissues and cell types, although they have distinct tissue expression patterns. The subcellular localization of class IX myosins appears to be partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. The expression level of myosins IX may vary during development and differentiation.
Alternate names: Myosin-IXb, Myr5
Gene ID 4650
NCBI Accession NP_004136.2
UniProt Q13459
Application Notes Peptide ELISA: 1/2000. Western Blot: 2 - 6 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Monsuur, de Bakker, Alizadeh et al.: "Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect." in: Nature genetics, Vol. 37, Issue 12, pp. 1341-4, 2005 (PubMed).

Alternatives for antigen "Myosin IXB (MYO9B)", type "Antibodies"
Hosts (8), (5), (2)
Reactivities (13), (8), (7)
Applications (12), (12)
Epitopes (3), (2), (1)
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