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Synaptic Vesicle Glycoprotein 2A (SV2A) (Internal Region) antibody

Details for Product No. ABIN374729, Supplier: Login to see
Antigen
  • AI746429
  • mKIAA0736
  • Sv2
  • SV2
Epitope
Internal Region
12
2
2
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
33
33
25
3
3
2
1
Host
Goat
24
15
2
1
Clonality
Polyclonal
Conjugate
Un-conjugated
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
29
18
11
5
2
2
1
1
Supplier
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Immunogen Peptide with sequence C-TVELYPSDKRTTA, from the internal region of the protein sequence
Specificity This antibody recognizes SV2A.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Human, Canine.
Species reactivity (tested):Rat.
Purification Affinity chromatography
Alternative Name SV2A (SV2A Antibody Abstract)
Background SV2s (Synaptic Vesicle protein 2) are integral membrane glycoproteins present in all synaptic vesicles. They have 12 transmembrane domains predicted by sequence analysis. There are three characterized isoforms, SV2A, SV2B and SV2C. SV2A is expressed ubiquitously throughout the brain. SV2B has a more restricted distribution with varying degrees of coexpression with SV2A. SV2C is more closely related to SV2A but shows a very restricted expression pattern. The highest expression levels were observed in phylogenetically old brain areas like pallidum, the midbrain and the olfactory bulb. SV2A is probably involved in the maintenance of a pool of synaptic vesicles competent for calcium-stimulated exocytosis. SV2A is a highly glycosylated synaptic vesicle protein with homology to transmembrane transporters.Synonyms: KIAA0736, Synaptic vesicle glycoprotein 2A
Gene ID 9900
NCBI Accession NP_055664
UniProt Q7L0J3
Research Area Neurology
Pathways
Application Notes Peptide ELISA: 1/64000. Western Blot: 0.3-1 μg/mL. Approx 80 kDa band observed in rat brain lysates (calculatedMW of 82.0 kDa according to NP_476558.1 (rat)). An additonal band of unknown identitywas also consistently observed at 20 kDa. This band was successfully blocked byincubation with the immunising peptide.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Synaptic Vesicle Glycoprotein 2A (SV2A) (Internal Region) antibody (ABIN374729) anti-Synaptic Vesicle Glycoprotein 2A (SV2A) (Internal Region) antibody
Background publications Dong, Yeh, Tepp et al.: "SV2 is the protein receptor for botulinum neurotoxin A." in: Science (New York, N.Y.), Vol. 312, Issue 5773, pp. 592-6, 2006 (PubMed).