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Details for Product No. ABIN374799

Tachykinin Receptor 1 (TACR1) (Internal Region) antibody

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Antigen
Synonyms SPR, NK1R, NKIR, TAC1R, Tac1r, Nk1r, Spr, nk1R, ASPR
Epitope
»Alternatives Internal Region
Reactivity
»Alternatives Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN374799
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide from the internal region of the protein sequence according to NP_001049.1, NP_056542.1. Genename: TACR1
Sequence C-EIPGDSSDRYHEQ
Specificity This antibody detects Tachykinin receptor 1 (TACR1). Species Reactivity: Tested: Human Expected from sequence similarity: Mouse, Rat, Dog
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Background The neurokinin-1 (NK1) receptor is a G-protein-coupled receptor characterized by seven transmembrane helices which preferentially binds the neuropeptide substance P. NK1 receptor (also known as the Substance P Receptor) plays a key role in pain and inflammation. Studies also implicate NK1 receptor in depression and the growth of brain tumors. The NK1 receptor has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach.
Alternate names: NK-1 receptor, NK-1R, NK1R, SPR, Substance-P receptor, TAC1R
Gene ID 6869
NCBI Accession 9606
UniProt P25103
Research Area Hormones, Receptors
Application Notes Peptide ELISA: antibody detection limit dilution 1: 32000. Western blot: 1-3µg/ml. Approx 36kDa band observed in Human Testis lysates (calculatedMW of 35.7kDa according to NP_056542.1). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Lai, Ho, Kilpatrick et al.: "Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 20, pp. 7771-6, 2006 (PubMed).

Garcia, Coello, Han et al.: "Partial loss compensation in dielectric-loaded plasmonic waveguides at near infra-red wavelengths." in: Optics express, Vol. 20, Issue 7, pp. 7771-6, 2012 (PubMed).

Alternatives for antigen "Tachykinin Receptor 1 (TACR1)", type "Antibodies"
Hosts (74), (5), (4)
Reactivities (66), (41), (35), (20), (17), (13), (12), (1), (1), (1), (1)
Applications (44), (22), (22), (18), (14), (10), (9), (6), (6), (5), (1)
Conjugates (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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