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Tachykinin Receptor 1 (TACR1) (Internal Region) antibody

Details for Product No. ABIN374799, Supplier: Log in to see
Antigen
  • NK1R
  • NKIR
  • SPR
  • TAC1R
  • Nk1r
  • Spr
  • Tac1r
  • nk1R
  • Tacr1
  • ASPR
Epitope
Internal Region
25
16
13
12
12
6
4
4
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
116
40
33
4
2
2
2
2
1
1
1
Host
Goat
106
13
7
Clonality
Polyclonal
Conjugate
Un-conjugated
7
7
6
3
3
3
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
77
47
31
14
11
9
7
5
3
2
Supplier
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Immunogen Peptide from the internal region of the protein sequence according to NP_001049.1, NP_056542.1. Genename: TACR1
Sequence C-EIPGDSSDRY HEQ
Specificity This antibody detects Tachykinin receptor 1 (TACR1).
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, DogSpecies reactivity (tested):Human
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Background The neurokinin-1 (NK1) receptor is a G-protein-coupled receptor characterized by seven transmembrane helices which preferentially binds the neuropeptide substance P. NK1 receptor (also known as the Substance P Receptor) plays a key role in pain and inflammation. Studies also implicate NK1 receptor in depression and the growth of brain tumors. The NK1 receptor has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach.Synonyms: NK-1 receptor, NK-1R, NK1R, SPR, Substance-P receptor, TAC1R
Gene ID 6869, 9606
UniProt P25103
Research Area Receptors, Hormones
Pathways
Application Notes Peptide ELISA: antibody detection limit dilution 1: 32000. Western blot: 1-3 μg/mL. Approx 36 kDa band observed in Human Testis lysates (calculatedMW of 35.6 kDa according to NP_056542.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Supplier Images
 image for anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibody (ABIN374799) anti-Tachykinin Receptor 1 (TACR1) (Internal Region) antibody
Background publications Garcia, Coello, Han et al.: "Partial loss compensation in dielectric-loaded plasmonic waveguides at near infra-red wavelengths." in: Optics express, Vol. 20, Issue 7, pp. 7771-6, 2012 (PubMed).

Lai, Ho, Kilpatrick et al.: "Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 20, pp. 7771-6, 2006 (PubMed).