Bridging Integrator 1 (BIN1) (Internal Region) antibody

Details for Product No. ABIN375175
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Antigen
Synonyms bin1, MGC53185, amph2, amphl, sh3p9, MGC76187, cb57, zgc:86701, BIN1, AMPH2, AMPHL, SH3P9, ALP-1, Amphl, BRAMP-2
Epitope
Internal Region
(3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(53), (35), (27), (13), (12), (3), (2)
Host
Goat
(31), (21), (3)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(41), (15), (12), (10), (8), (7), (5), (3), (3), (2), (2), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN375175
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Immunogen Peptide with sequence C-SDNAPAKGNKSPS, from the internal region of the protein sequence
Specificity This antibody reacts to BIN1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Bovine.
Purification Affinity chromatography
Alternative Name BIN1 / AMPHL
Background The identification and analysis of tumor suppressors is of major importance for improved diagnosis and treatment of tumors. Bin1 (Box-dependent myc interacting protein 1, also known as SH3P9, amphiphysin II and amphl/amphiphysin-like) is a novel protein that has features of a tumor suppressor. Bin1 interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Bin1 also interacts with HCV NS5A through its SH3 domain.
Alternate names: Amphiphysin II, Amphiphysin-like protein, Box-dependent myc-interacting protein 1, Bridging integrator 1, Myc box-dependent-interacting protein 1
Gene ID 274
NCBI Accession NP_004296
UniProt O00499
Application Notes Peptide ELISA: 1/1000. Western Blot: 1 - 3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Bridging Integrator 1 (BIN1) (Internal Region) antibody anti-Bridging Integrator 1 (BIN1) (Internal Region) antibody
Background publications Ghaneie, Zemba-Palko, Itoh et al.: "Bin1 attenuation in breast cancer is correlated to nodal metastasis and reduced survival." in: Cancer biology & therapy, Vol. 6, Issue 2, pp. 192-4, 2007 (PubMed).

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