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BCL2/adenovirus E1B 19kDa Interacting Protein 1 (BNIP1) (Internal Region), (Isoform 1) antibody

Details for Product No. ABIN375177
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Antigen
Synonyms NIP1, SEC20, TRG-8, 2010005M06Rik, 5930429G21Rik, Sec20, 2900010M17Rik, AI853434, Apba2bp, Nip1, XB51
Epitope
Internal Region, Isoform 1
(9), (8), (3), (2), (2), (2), (2), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(52), (18), (16), (12), (12), (12)
Host
Goat
(40), (9), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(43), (20), (10), (9), (5), (3), (2), (1), (1), (1)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN375177
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Immunogen Peptide with sequence C-DLLRQRKTTKESLAQ, from the internal region of the protein sequence
Specificity This antibody reacts to BNIP1. All reported variants represent isoform 1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat.
Purification Affinity chromatography
Alternative Name BNIP1
Background BNIPs belong to the proapoptotic BH3-only protein family. Three isoforms have been described so far. BNIP 1 is involved in the maintenance of ER-integrity. It is a member of the syntaxin 18 complex which is involved in membrane trafficking between the ER and Golgi. Four different BNIP 1 splice variants have been described so far, one of which contains a highly conserved BH3 domain. All BNIP 1 variants are able to interact with the apoptosis regulators BCL2 and BCL2L1.
Alternate names: BCL2/adenovirus E1B 19 kDa protein-interacting protein 1, NIP1, SEC20L, TRG8, Transformation-related gene 8 protein, Vesicle transport protein SEC20
Gene ID 662
NCBI Accession NP_001196.2
UniProt Q12981
Research Area Signaling, Apoptosis/Necrosis
Application Notes Peptide ELISA: 1/8000. Western Blot: 0.5 - 1.5 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-BCL2/adenovirus E1B 19kDa Interacting Protein 1 (BNIP1) (Internal Region), (Isoform 1) antibody anti-BCL2/adenovirus E1B 19kDa Interacting Protein 1 (BNIP1) (Internal Region), (Isoform 1) antibody
Background publications Nakajima, Hirose, Taniguchi et al.: "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion." in: The EMBO journal, Vol. 23, Issue 16, pp. 3216-26, 2004 (PubMed).

Validation Images
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