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Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (Internal Region) antibody

Details for Product No. ABIN375218, Supplier: Log in to see
Antigen
  • NEDD9
  • CAS-L
  • CAS2
  • CASL
  • CASS2
  • HEF1
  • Cas-L
  • CasL
  • E230025G09Rik
Epitope
Internal Region
18
12
10
10
4
4
4
3
3
2
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
65
15
12
4
2
1
1
1
Host
Goat
35
17
13
Clonality
Polyclonal
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
58
30
20
13
10
5
2
2
1
1
1
Supplier
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Immunogen Peptide with sequence NKPQNKCDDLDR, from the internal region of the protein sequence
Specificity This antibody reacts to NEDD9. This antibody is expected to recognise isoform 1 only.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat, Canine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Alternative Name NEDD9 (NEDD9 Antibody Abstract)
Background HEF1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis and oncogenic transformation. The Cas family of docking proteins have been the subject of intense research because of their role in cell motility, growth, apoptosis and oncogenic transformation. These proteins are substrates of focal adhesion kinase (FAK) and the Src family of tyrosine kinases, two active targets for drug development. HEF1 protein production increases levels of mRNA transcripts that encode proteins associated with motility, cell transformation and invasiveness, including several metalloproteinases, MLCK, p160ROCK and ErbBi. HEF1 overproduction also mediates apoptosis in epithelial-derived cell lines, including MCF7 and HeLa cells. Recent clinical studies at another institution have found that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance. This highlights the importance of studying the role of this family of proteins in cancer prognosis.Synonyms: CASL, CASS2, Enhancer of filamentation 1, Neural precursor cell expressed developmentally down-regulated protein 9, hEF1
Gene ID 4739
NCBI Accession NP_001135865
UniProt Q14511
Research Area Cell Cycle, Signaling
Pathways
Application Notes Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (Internal Region) antibody (ABIN375218) anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (Internal Region) antibody
Background publications Kim, Gans, Nogueira et al.: "Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene." in: Cell, Vol. 125, Issue 7, pp. 1269-81, 2006 (PubMed).