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SET7 antibody (C-Term)

SETD8P1 Reactivity: Human WB Host: Rabbit Polyclonal RB5744 unconjugated
Catalog No. ABIN387998
  • Target See all SET7 (SETD8P1) Antibodies
    SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))
    Binding Specificity
    • 6
    • 5
    • 5
    • 2
    • 1
    AA 289-317, C-Term
    Reactivity
    • 15
    • 2
    Human
    Host
    • 14
    • 1
    Rabbit
    Clonality
    • 14
    • 1
    Polyclonal
    Conjugate
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    This SET7 antibody is un-conjugated
    Application
    • 14
    • 12
    • 7
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This SET7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 289-317 amino acids from the C-terminal region of human SET7.
    Clone
    RB5744
    Isotype
    Ig Fraction
    Top Product
    Discover our top product SETD8P1 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Expiry Date
    6 months
  • Target
    SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))
    Alternative Name
    SET7 (SETD8P1 Products)
    Synonyms
    KMT7 antibody, SET7 antibody, SET7/9 antibody, SET9 antibody, 1600028F23Rik antibody, H3K4MT antibody, Set7 antibody, Set7/9 antibody, mKIAA1717 antibody, SET domain containing lysine methyltransferase 7 antibody, SET domain containing (lysine methyltransferase) 7 antibody, SETD7 antibody, Setd7 antibody
    Background
    Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. Signal transduction pathways affecting the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Set7/9 is a histone specific HMTase that methylates histone H3 lysine 4. Set7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. In yeast, H4-K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function, rather it appears to play a role in DNA damage response. Loss of Set9 activity or mutation of H4-K20 markedly impairs yeast cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest. Genetic experiments link Set9 to Crb2, a homolog of the mammalian checkpoint protein 53BP1, and the enzyme is required for Crb2 localization to sites of DNA damage.
    Molecular Weight
    40721
    Gene ID
    80854
    NCBI Accession
    NP_085151
    UniProt
    Q8WTS6
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