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SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (AA 49-81), (C-Term) antibody

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Synonyms SUMO2
AA 49-81, C-Term
(16), (7), (6), (3), (3), (2), (2), (2), (2), (1), (1), (1)
Human, Mouse (Murine)
(59), (27), (24), (2), (2), (1), (1)
(51), (6), (2)
Clonality (Clone)
Polyclonal ()
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(43), (22), (22), (13), (11), (7), (2), (1), (1)
Pubmed 9 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-81 AA from the C-terminal region of human SUMO2/3.
Clone RB00635
Isotype Ig
Specificity This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58~88 amino acids within C-terminal region of human SUMO2/3.
Predicted Reactivity Cow (Bovine),Chicken,Hamster,Pig (Porcine),Monkey,Rat (Rattus),Xenopus laevis,Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SUMO2/3
Background SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
Synonyms: Small ubiquitin-like modifier, Ubiquitin-like protein SMT3B, Sentrin 2, HSMT3
Molecular Weight 11637 DA
Gene ID 6612
UniProt P55854
Research Area Apoptosis/Necrosis, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (AA 49-81), (C-Term) antibody (ABIN388034) The anti-SUMO2/3 C-term Pab (ABIN388034) is used in Western blot to detect SUMO2/3 in...
Western Blotting (WB) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (AA 49-81), (C-Term) antibody (ABIN388034) COS-7 cells were transfected for 24 hrs with a plasmid expressing DYKDDDDK-ERM (left ...
Immunohistochemistry (IHC) image for anti-SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (AA 49-81), (C-Term) antibody (ABIN388034) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Product cited in: Higginbotham, OShea: "Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains." in: Journal of virology, Vol. 89, Issue 20, pp. 10260-72, 2015 (PubMed).

Heo, Lee, Nigro et al.: "PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation." in: The Journal of cell biology, Vol. 193, Issue 5, pp. 867-84, 2011 (PubMed).

Snider, Weerasinghe, Iñiguez-Lluhí et al.: "Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation." in: The Journal of biological chemistry, Vol. 286, Issue 3, pp. 2273-84, 2011 (PubMed).

Nadtochiy, Redman, Rahman et al.: "Lysine deacetylation in ischaemic preconditioning: the role of SIRT1." in: Cardiovascular research, Vol. 89, Issue 3, pp. 643-9, 2011 (PubMed).

Cho, Yi, Tserentsoodol et al.: "Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress." in: Disease models & mechanisms, Vol. 3, Issue 9-10, pp. 595-604, 2010 (PubMed).

Martin, Schwamborn, Urlaub et al.: "Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity." in: Molecular and cellular biology, Vol. 28, Issue 8, pp. 2771-81, 2008 (PubMed).

Degerny, Monte, Beaudoin et al.: "SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24330-8, 2005 (PubMed).

Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Lapenta, Chiurazzi, van der Spek et al.: "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family." in: Genomics, Vol. 40, Issue 2, pp. 362-6, 1997 (PubMed).

Catalog No. ABIN388034
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