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BCL2-Like 2 (BCL2L2) (AA 24-59), (BH3 Domain) antibody

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Synonyms bcl2l2, BCL2L2, BCL-W, BCL2-L-2, BCLW, PPP1R51, AW048834, Bcl-w, Gtrgal2, Gtrosa41, bclw, c98, BCL-WEL, BCL-WS, Bclw
AA 24-59, BH3 Domain
(15), (11), (9), (5), (5), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Human, Mouse (Murine)
(105), (48), (35), (8), (3), (1)
(99), (11), (4), (2), (1)
Clonality (Clone)
Polyclonal ()
(9), (8), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(73), (56), (33), (14), (11), (11), (9), (6), (5), (2), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This Bcl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-59 AA from human Bcl.
Clone RB0972
Isotype Ig
Specificity This Bcl-w antibody was developed against a synthetic peptide corresponding within amino acid residues 1-100 of human Bcl-W.
Predicted Reactivity Cow (Bovine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bcl-w (BCL2L2 Antibody Abstract)
Background Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.
Synonyms: Bcl2-like protein 2, BCL2L2
Molecular Weight 20774 DA
Gene ID 599
UniProt Q92843
Research Area Apoptosis/Necrosis, Cancer, Neurology
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BCL2-Like 2 (BCL2L2) (AA 24-59), (BH3 Domain) antibody (ABIN388097) Western blot analysis of anti-Bcl-w BH3 domain Pab (ABIN388097) in HL-60 cell lysate....
Western Blotting (WB) image for anti-BCL2-Like 2 (BCL2L2) (AA 24-59), (BH3 Domain) antibody (ABIN388097) Western blot analysis of Bcl-w3 (arrow) using rabbit polyclonal Bcl-w BH3 Domain Anti...
Immunohistochemistry (IHC) image for anti-BCL2-Like 2 (BCL2L2) (AA 24-59), (BH3 Domain) antibody (ABIN388097) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Hinds, Lackmann, Skea et al.: "The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity." in: The EMBO journal, Vol. 22, Issue 7, pp. 1497-507, 2003 (PubMed).

Denisov, Madiraju, Chen et al.: "Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 21124-8, 2003 (PubMed).

Middleton, Wyatt, Ninkina et al.: "Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival." in: Development (Cambridge, England), Vol. 128, Issue 3, pp. 447-57, 2001 (PubMed).

Gibson, Holmgreen, Huang et al.: "bcl-w, a novel member of the bcl-2 family, promotes cell survival." in: Oncogene, Vol. 13, Issue 4, pp. 665-75, 1996 (PubMed).

Catalog No. ABIN388097
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