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Details for Product No. ABIN388097

BCL2-Like 2 (BCL2L2) (AA 24-59), (BH3 Domain) antibody

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Synonyms BCL-W, BCL2-L-2, BCLW, PPP1R51, AW048834, Bcl-w, Gtrgal2, Gtrosa41, bclw, c98, BCL-WEL, BCL-WS, Bclw, bcl2l2, BCL2L2
»Alternatives AA 24-59, BH3 Domain
»Alternatives Human, Mouse (Murine)
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN388097
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This Bcl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-59 AA from human Bcl.
Clone RB0972
Isotype Ig
Specificity This Bcl-w antibody was developed against a synthetic peptide corresponding within amino acid residues 1-100 of human Bcl-W.
Predicted Reactivity Cow (Bovine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bcl-w
Background Bcl-w is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis.
Synonyms: Bcl2-like protein 2, BCL2L2
Molecular Weight 20774 DA
Gene ID 599
UniProt Q92843
Research Area Apoptosis/Necrosis, Cancer, Neurology
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Gibson, Holmgreen, Huang et al.: "bcl-w, a novel member of the bcl-2 family, promotes cell survival." in: Oncogene, Vol. 13, Issue 4, pp. 665-75, 1996 (PubMed).

Middleton, Wyatt, Ninkina et al.: "Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival." in: Development (Cambridge, England), Vol. 128, Issue 3, pp. 447-57, 2001 (PubMed).

Denisov, Madiraju, Chen et al.: "Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 21124-8, 2003 (PubMed).

Hinds, Lackmann, Skea et al.: "The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity." in: The EMBO journal, Vol. 22, Issue 7, pp. 1497-507, 2003 (PubMed).

Alternatives for antigen "BCL2-Like 2 (BCL2L2)", type "Antibodies"
Hosts (51), (7), (3), (1)
Reactivities (59), (43), (39), (19), (17), (5), (5)
Applications (42), (20), (15), (14), (10), (8), (6), (5), (3), (2), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (3), (2), (2), (1), (1), (1), (1), (1)