Bone Morphogenetic Protein 3 (BMP3) (N-Term), (AA 8-36) antibody

Details for Product No. ABIN388453
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Antigen
Synonyms wu:fk96e01, BMP3, zgc:153939, BMP-3A, 9130206H07, 9530029I04Rik, PBMP3, BMP-3, xBMP-3
Epitope
N-Term, AA 8-36
(14), (11), (9), (7), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(80), (23), (23), (13), (12), (12), (12)
Host
Rabbit
(75), (5), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(68), (45), (17), (12), (10), (2), (2), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN388453
291.50 $
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Immunogen This Bmp3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-36 AA from the N-terminal region of human Bmp3.
Clone RB1855-1856
Isotype Ig
Specificity This Bmp3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15~44 amino acids from the N-terminal region of human Bmp3.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bmp3
Background The BMPs belong to the TGF-Beta superfamilyBMPs stimulate the production of bone matrix proteins and thereby alter stromal cell and osteoclast proliferation, a key step in bone marrow development. In addition to promoting ectopic bone and cartilage development, BMPs regulate the growth, differentiation, chemotaxis, proliferation, and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells, and neuronal cells. BMPs also play a role in dorsal/ventral patterning. BMP3, highly expressed in lung, ovary and small intestine, participates in cartilage and bone formation. BMP3 and BMP2 genes map to conserved regions between human and mouse.
Molecular Weight 53406 DA
Gene ID 651
UniProt P12645
Research Area Cell Signaling, Cell Cycle, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Bone Morphogenetic Protein 3 (BMP3) (N-Term), (AA 8-36) antibody Western blot analysis of hBmp3-E23 (ABIN388453) in 293 cell line lysates (35 µg/lane). BMP3 (arrow) was detected using the purified polyclonal antibody.
anti-Bone Morphogenetic Protein 3 (BMP3) (N-Term), (AA 8-36) antibody (2) Western blot analysis of Bmp3 (arrow) using rabbit polyclonal Bmp3 Antibody (N-term) (ABIN388453). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the Bmp3 gene (Lane 2) (Origene Technologies).
anti-Bone Morphogenetic Protein 3 (BMP3) (N-Term), (AA 8-36) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Dickinson, Kobrin, Silan et al.: "Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci." in: Genomics, Vol. 6, Issue 3, pp. 505-20, 1990 (PubMed).

Wozney, Rosen, Celeste et al.: "Novel regulators of bone formation: molecular clones and activities." in: Science (New York, N.Y.), Vol. 242, Issue 4885, pp. 1528-34, 1989 (PubMed).

Jin, Lu, Liong et al.: "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors." in: Histology and histopathology, Vol. 16, Issue 4, pp. 1013-9, 2001 (PubMed).

Validation Images
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