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Details for Product No. ABIN388456

Bone Morphogenetic Protein 6 (BMP6) (N-Term), (AA 25-55) antibody

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Antigen
Synonyms VGR, VGR1, Vgr1, D13Wsu115e, BMP6, zgc:113595, vgr, vgr-1, vgr1
Epitope
»Alternatives N-Term, AA 25-55
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 4 references available
Catalog no. ABIN388456
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 AA from the N-terminal region of human Bmp6.
Clone RB01862
Isotype Ig
Specificity This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33~62 amino acids from the N-terminal region of human Bmp6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bmp6
Background The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Molecular Weight 57225 DA
Gene ID 654
UniProt NP_001709
Research Area Cell Signaling, Cell Cycle, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Olavesen, Bentley, Mason et al.: "Fine mapping of 39 ESTs on human chromosome 6p23-p25." in: Genomics, Vol. 46, Issue 2, pp. 303-6, 1998 (PubMed).

Tamada, Kitazawa, Gohji et al.: "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)." in: Biochimica et biophysica acta, Vol. 1395, Issue 3, pp. 247-51, 1998 (PubMed).

Bobacz, Gruber, Soleiman et al.: "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro." in: Arthritis and rheumatism, Vol. 48, Issue 9, pp. 2501-8, 2003 (PubMed).

Lories, Derese, Ceuppens et al.: "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis." in: Arthritis and rheumatism, Vol. 48, Issue 10, pp. 2807-18, 2003 (PubMed).

Alternatives for antigen "Bone Morphogenetic Protein 6 (BMP6)", type "Antibodies"
Hosts (55), (8), (1), (1)
Reactivities (57), (26), (19), (16), (15), (15), (12)
Applications (47), (28), (20), (12), (10), (6), (4), (2), (2), (2), (1), (1)
Conjugates (9), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (4), (3), (2), (2), (2), (1), (1), (1), (1)
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