Bone Morphogenetic Protein 6 (BMP6) (N-Term), (AA 25-55) antibody

Details for Product No. ABIN388456
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Antigen
Epitope
N-Term, AA 25-55
(10), (5), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(64), (25), (19), (16), (15), (15), (12)
Host
Rabbit
(59), (9), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(8), (5), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(53), (30), (18), (15), (11), (6), (6), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 400 μL
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Catalog No. ABIN388456
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Immunogen This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-55 AA from the N-terminal region of human Bmp6.
Clone RB01862
Isotype Ig
Specificity This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33~62 amino acids from the N-terminal region of human Bmp6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name Bmp6
Background The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
Molecular Weight 57225 DA
Gene ID 654
NCBI Accession NP_001709
Research Area Cell Signaling, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 1.45 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Bone Morphogenetic Protein 6 (BMP6) (N-Term), (AA 25-55) antibody The anti-Bmp6 (N-term) Pab (ABIN388456) is used in Western blot to detect Bmp6 in HL60 cell lysate.
anti-Bone Morphogenetic Protein 6 (BMP6) (N-Term), (AA 25-55) antibody (2) Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with Bmp6 antibody (N-term)(ABIN388456), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Olavesen, Bentley, Mason et al.: "Fine mapping of 39 ESTs on human chromosome 6p23-p25." in: Genomics, Vol. 46, Issue 2, pp. 303-6, 1998 (PubMed).

Tamada, Kitazawa, Gohji et al.: "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)." in: Biochimica et biophysica acta, Vol. 1395, Issue 3, pp. 247-51, 1998 (PubMed).

Bobacz, Gruber, Soleiman et al.: "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro." in: Arthritis and rheumatism, Vol. 48, Issue 9, pp. 2501-8, 2003 (PubMed).

Lories, Derese, Ceuppens et al.: "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis." in: Arthritis and rheumatism, Vol. 48, Issue 10, pp. 2807-18, 2003 (PubMed).

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