UV Radiation Resistance Associated Gene (UVRAG) (AA 366-398), (Center) antibody

Details for Product No. ABIN388587
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Antigen
Epitope
AA 366-398, Center
(4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(32), (19), (15), (12), (1)
Host
Rabbit
(27), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(22), (12), (10), (9), (5), (4), (3), (2), (1)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN388587
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Immunogen This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-398 AA from the Central region of human UVRAG.
Clone RB10847
Isotype Ig
Specificity This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375~404 amino acids from the center of human UVRAG.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UVRAG
Background UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Synonyms: UV radiation resistance-associated gene protein, p63
Molecular Weight 78151 DA
Gene ID 7405
UniProt Q9P2Y5
Research Area Cell Signaling, Cancer, Autophagy, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-UV Radiation Resistance Associated Gene (UVRAG) (AA 366-398), (Center) antibody Western blot analysis of anti-hUVRAG (Center) Pab (ABIN388587) in mouse heart tissue lysates. hUVRAG (Center)(arrow) was detected using the purified polyclonal antibody.
anti-UV Radiation Resistance Associated Gene (UVRAG) (AA 366-398), (Center) antibody (2) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hUVRAG (Center) (ABIN388587), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Perelman, Dafni, Naiman et al.: "Molecular cloning of a novel human gene encoding a 63-kDa protein and its sublocalization within the 11q13 locus." in: Genomics, Vol. 41, Issue 3, pp. 397-405, 1997 (PubMed).

Ionov, Nowak, Perucho et al.: "Manipulation of nonsense mediated decay identifies gene mutations in colon cancer Cells with microsatellite instability." in: Oncogene, Vol. 23, Issue 3, pp. 639-45, 2004 (PubMed).

Liang, Feng, Ku et al.: "Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG." in: Nature cell biology, Vol. 8, Issue 7, pp. 688-99, 2006 (PubMed).

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