UVRAG antibody (AA 366-398)

Catalog No. ABIN388587

Product Details anti-UVRAG Antibody

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Binding Specificity: AA 366-398

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UVRAG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This UVRAG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 366-398 amino acids from the Central region of human UVRAG.

Clone: RB10847

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for UVRAG

Target: UVRAG (UV Radiation Resistance Associated Gene (UVRAG))

Alternative Name: UVRAG (UVRAG Products)

Synonyms: DHTX antibody, VPS38 antibody, p63 antibody, 9530039D02Rik antibody, AI648770 antibody, BB124205 antibody, Uvrag1 antibody, Uvragl antibody, zgc:56164 antibody, uvrag antibody, MGC81810 antibody, UVRAG antibody, MGC131135 antibody, CG6116 antibody, Dmel\\CG6116 antibody, UV radiation resistance associated antibody, UV radiation resistance associated gene antibody, UV radiation resistance associated S homeolog antibody, UV radiation resistance associated L homeolog antibody, UV-resistance associated gene antibody, UVRAG antibody, Uvrag antibody, uvrag antibody, uvrag.S antibody, uvrag.L antibody

Background: UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.

Molecular Weight: 78151

Gene ID: 7405

NCBI Accession: NP_003360

UniProt: Q9P2Y5