Non-SMC Condensin II Complex, Subunit H2 (NCAPH2) (AA 198-227), (N-Term) antibody

Details for Product No. ABIN388692
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Antigen
Epitope
AA 198-227, N-Term
(18), (2), (1)
Reactivity
Human
(25), (5), (5), (2), (1)
Host
Rabbit
(23), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(22), (9), (5), (3), (2), (2), (1)
Pubmed 4 references available
Quantity 400 μL
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Immunogen This NCAPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 198-227 AA from the N-terminal region of human NCAPH2.
Clone RB9657
Isotype Ig
Specificity This NCAPH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human NCAPH2.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name NCAPH2 (NCAPH2 Antibody Abstract)
Background Structural maintenance of chromosomes (SMC) and non-SMC condensin proteins associate into complexes that have been implicated in the process of chromosome condensation. A crucial prerequisite for accurate segregation of replicated sister chromatids is the condensation of the chromosomes into a manageable form prior to metaphase. The condensin I complex consists of two SMC subunits, SMC2 and SMC4, and three non-SMC subunits, CAP-H, CAP-G, and CAP-D2. An alternative complex, the condensin II complex, contains alternate non-SMC subunits, CAP-G2, CAP-H2, and CAP-D3. CAP-H2 is also known as Non-SMC condensin II complex, subunit H2 (NCAPH2) or kleisin beta isoform 2. The three non-SMC subunits in the condensing complexes form a regulatory subcomplex that is required to activate the SMC ATPases and to promote mitosis-specific chromatin binding of the holocomplex. The precise individual functions of each non-SMC protein in activation remain to be determined.
Synonyms: Non-SMC condensin II complex, subunit H2, NCAPH2,
Molecular Weight 62463 DA
Gene ID 29781
UniProt Q9BUT3
Research Area Signaling, Chromatin
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Non-SMC Condensin II Complex, Subunit H2 (NCAPH2) (AA 198-227), (N-Term) antibody Western blot analysis of anti-NCAPH2 Pab (ABIN388692) in HepG2 cell line lysate (35 µ...
Product cited in: Lai, Wong, Lee et al.: "Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death." in: Cell death and differentiation, Vol. 18, Issue 6, pp. 996-1004, 2011 (PubMed).

Lisková, Susor, Pivonková et al.: "Detection of condensin I and II in maturing pig oocytes." in: Reproduction, fertility, and development, Vol. 22, Issue 4, pp. 644-52, 2010 (PubMed).

Background publications Ono, Losada, Hirano et al.: "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells." in: Cell, Vol. 115, Issue 1, pp. 109-21, 2003 (PubMed).

Schleiffer, Kaitna, Maurer-Stroh et al.: "Kleisins: a superfamily of bacterial and eukaryotic SMC protein partners." in: Molecular cell, Vol. 11, Issue 3, pp. 571-5, 2003 (PubMed).

Validation Images
Catalog No. ABIN388692
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