Growth Differentiation Factor 11 (GDF11) (N-Term), (AA 32-61) antibody

Details for Product No. ABIN388814
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Antigen
Epitope
N-Term, AA 32-61
(8), (6), (1), (1), (1)
Reactivity
Human
(33), (11), (11), (11), (11), (1)
Host
Rabbit
(26), (8)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(21), (18), (9), (8), (7), (2), (2), (1)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN388814
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Immunogen This GDF11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 AA from the N-terminal region of human GDF11.
Clone RB01875-01876
Isotype Ig
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name GDF11
Background GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.

Synonyms: Growth/differentiation factor 11 [Precursor], GDF-11, Bone morphogenetic protein 11, GDF11, BMP11
Molecular Weight 45090 Da
Gene ID 10220
UniProt O95390
Research Area Stem Cells, Cell Signaling, Neurology, Cell Structure
Application Notes Suggested dilutions:
WB = 1:1000, IHC = 1:10-50
Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots.
Expiry Date 6 months
Supplier Images
anti-Growth Differentiation Factor 11 (GDF11) (N-Term), (AA 32-61) antibody Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with GDF11 antibody (N-term) (ABIN388814), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Growth Differentiation Factor 11 (GDF11) (N-Term), (AA 32-61) antibody (2) Western blot analysis of GDF11 (arrow) using rabbit polyclonal GDF11 Antibody (R47) (ABIN388814).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the GDF11 gene (Lane 2) (Origene Technologies).
Background publications Gamer, Wolfman, Celeste et al.: "A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos." in: Developmental biology, Vol. 208, Issue 1, pp. 222-32, 1999 (PubMed).

Lee, McPherron: "Myostatin and the control of skeletal muscle mass." in: Current opinion in genetics & development, Vol. 9, Issue 5, pp. 604-7, 1999 (PubMed).

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