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Ubiquitin Conjugation Factor E4 B (UBE4B) (N-Term), (AA 112-142) antibody

Details for Product No. ABIN388841
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Antigen
Epitope
N-Term, AA 112-142
(10), (3), (2), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(26), (4), (3)
Host
Rabbit
(23), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(24), (14), (7), (5), (3), (1), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN388841
291.50 $
Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This UBE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-142 AA from the N-terminal region of human UBE4B.
Clone RB4133
Isotype Ig
Specificity This UBE4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120~149 amino acids from the N-terminal region of human UBE4B.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UBE4B
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE4B represents an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. UBE4B also the strongest candidate among the neuroblastoma tumor suppressors.
Synonyms: Ubiquitin conjugation factor E4 B, Ubiquitin-fusion degradation protein 2, Homozygously deleted in neuroblastoma-1, HDNB1, KIAA0684, UFD2
Molecular Weight 133275 DA
Gene ID 10277
UniProt O95155
Research Area Ubiquitin-related antibodies, Apoptosis/Necrosis, Protein Modifications, Cancer, Neurology, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Ubiquitin Conjugation Factor E4 B (UBE4B) (N-Term), (AA 112-142) antibody The anti-UBE4B Pab (ABIN388841) is used in Western blot to detect UBE4B in mouse kidney tissue lysate.
anti-Ubiquitin Conjugation Factor E4 B (UBE4B) (N-Term), (AA 112-142) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Ishikawa, Nagase, Suyama et al.: "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 3, pp. 169-76, 1998 (PubMed).

Mahoney, Odin, White et al.: "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis." in: The Biochemical journal, Vol. 361, Issue Pt 3, pp. 587-95, 2002 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN388841
291.50 $
Plus shipping costs $45.00
Add to Basket

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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