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Details for Product No. ABIN388848

Ubiquitin-Conjugating Enzyme E2B (UBE2B) (C-Term), (AA 117-146) antibody

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Antigen
Synonyms HR6B, UBC2, HHR6B, RAD6B, E2-17kDa, Rad6b, mHR6B, E2-14k, 2610301N02Rik, hhr6b, hr6b, rad6b, ubc2, fc79h10, wu:fc79h10, zgc:100921, e2-17kda
Epitope
»Alternatives C-Term, AA 117-146
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (IHC), Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN388848
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This UBE2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 117-146 AA from the C-terminal region of human UBE2B.
Clone RB4331
Isotype Ig
Specificity This UBE2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human UBE2B.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name UBE2B
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. UBE2B is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Synonyms: Ubiquitin-conjugating enzyme E2 B, Ubiquitin-protein ligase B, Ubiquitin carrier protein B, HR6B, hHR6B, E2-17 kDa
Molecular Weight 17312 DA
Gene ID 7320
UniProt NP_003328
Research Area Ubiquitin-related antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes Recommend dilutions: IHC : 1:50-100,WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Koken, Smit, Jaspers-Dekker et al.: "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31." in: Genomics, Vol. 12, Issue 3, pp. 447-53, 1992 (PubMed).

Koken, Reynolds, Jaspers-Dekker et al.: "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 8865-9, 1991 (PubMed).

Schneider, Eckerskorn, Lottspeich et al.: "The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6." in: The EMBO journal, Vol. 9, Issue 5, pp. 1431-5, 1990 (PubMed).

Alternatives for antigen "Ubiquitin-Conjugating Enzyme E2B (UBE2B)", type "Antibodies"
Hosts (24), (8)
Reactivities (31), (16), (15), (12), (1), (1), (1), (1), (1), (1)
Applications (21), (15), (10), (6), (3), (3), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (3), (3), (1)
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