Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (C-Term), (AA 840-870) antibody

Details for Product No. ABIN388933
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Synonyms AF1P, AF-1P, MLLT5, 2410112D09Rik, RGD1307641, CG16932, Dmel\\CG16932, EH1, EPS-15, Eps15, anon-WO0118547.85, eps-15, eps15, i31
C-Term, AA 840-870
(12), (7), (6), (6), (2), (1)
(34), (33), (33), (12), (1)
Clonality (Clone)
Polyclonal ()
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(30), (16), (16), (10), (9), (3)
Pubmed 3 references available
Catalog no. ABIN388933
Quantity 400 µL
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Immunogen This EPS15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 840-870 AA from the C-terminal region of human EPS15.
Clone RB04393-04394
Isotype Ig
Specificity This EPS15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 848~877 amino acids from the C-terminal region of human EPS15.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name EPS15
Background EPS15 is involved in cell growth regulation, possibly via the regulation of mitogenic signals and control of cell proliferation. EPS15 also participates in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Potential interaction partners include AP2A2, STN2, EPN1, and CRK via its SH3-binding sites. EPS15 is ubiquitously expressed. Phosphorylation on Tyr-849 is involved in the internalization of EGFR. EPS15 is not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis. This protein is involved in a t(1,11)(p32,q23) chromosomal translocation in acute leukemias causing fusion to the trithorax (MLL or HRX) gene product which contains DNA-binding motifs resulting in a rogue activator protein. Structurally, EPS15 contains 2 EF-hand calcium-binding domains, 3 EH domains, and 2 ubiquitin-interacting motif (UIM) repeats.
Molecular Weight 98673 DA
Gene ID 2060
UniProt NP_001972
Research Area Ubiquitin-related antibodies, Cell Structure, Protein Modifications, Cancer, Cell Cycle
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15) (C-Term), (AA 840-870) antibody Western blot analysis of anti-EPS15 Pab (ABIN388933) in HL60 cell line lysate (35 µg/lane). EPS15 (arrow) was detected using the purified polyclonal antibody.
Background publications Matsuda, Ota, Tanimura et al.: "Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins." in: The Journal of biological chemistry, Vol. 271, Issue 24, pp. 14468-72, 1996 (PubMed).

de Beer, Carter, Lobel-Rice et al.: "Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain." in: Science (New York, N.Y.), Vol. 281, Issue 5381, pp. 1357-60, 1998 (PubMed).

Chen, Fre, Slepnev et al.: "Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis." in: Nature, Vol. 394, Issue 6695, pp. 793-7, 1998 (PubMed).

Hosts (42)
Reactivities (34), (33), (33), (12), (1)
Applications (30), (16), (16), (10), (9), (3)
Conjugates (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (7), (6), (6), (2), (1)
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