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Acyl-CoA Synthetase Long-Chain Family Member 6 (ACSL6) (AA 240-270), (Center) antibody

Details for Product No. ABIN389115, Supplier: Login to see
Antigen
  • ACSL6
  • acsl6
  • MGC146229
  • FACL6
  • ACS2
  • LACS 6
  • LACS2
  • LACS5
  • A330035H04Rik
  • AW050338
  • Facl6
  • LACS
  • Lacsl
  • mKIAA0837
Epitope
AA 240-270, Center
20
11
3
2
2
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
43
15
9
Host
Rabbit
43
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
38
22
21
5
1
Supplier
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Immunogen This FACL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-270 AA from the Central region of human FACL6.
Clone RB4703
Isotype Ig
Specificity This FACL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247~277 amino acids from the center region of human FACL6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FACL6 (ACSL6 Antibody Abstract)
Background FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5,12)(q31,p13) that involves ETV6 and ACSL6.
Synonyms: Long-chain-fatty-acid--CoA ligase 6, Long-chain acyl-CoA synthetase 6, LACS 6
Molecular Weight 77680 DA
Gene ID 23305
Research Area Protein Modifications, Cancer, Metabolism, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Acyl-CoA Synthetase Long-Chain Family Member 6 (ACSL6) (AA 240-270), (Center) antibody (ABIN389115) The anti-FACL6 Pab (ABIN389115) is used in Western blot to detect FACL6 in mouse live...
Immunohistochemistry (IHC) image for anti-Acyl-CoA Synthetase Long-Chain Family Member 6 (ACSL6) (AA 240-270), (Center) antibody (ABIN389115) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Yagasaki, Jinnai, Yoshida et al.: "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)." in: Genes, chromosomes & cancer, Vol. 26, Issue 3, pp. 192-202, 2000 (PubMed).