Acyl-CoA Synthetase Long-Chain Family Member 6 (ACSL6) (AA 240-270), (Center) antibody

Details for Product No. ABIN389115
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Antigen
Synonyms ACS2, FACL6, LACS 6, LACS2, LACS5, Facl6, Lacsl, A330035H04Rik, AW050338, LACS, mKIAA0837, ACSL6, acsl6, MGC146229
Epitope
AA 240-270, Center
(4), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(19), (10), (8)
Host
Rabbit
(19)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(18), (10), (5), (2), (1), (1)
Pubmed 1 reference available
Catalog no. ABIN389115
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This FACL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-270 AA from the Central region of human FACL6.
Clone RB4703
Isotype Ig
Specificity This FACL6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247~277 amino acids from the center region of human FACL6.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name FACL6
Background FACL6 is involved in activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. It plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. FACL6 is expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derieved from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain. Expression is low at earlier stages of erythroid development but is very high in reticulocytes. This protein is involved in myelodysplastic syndrome (MDS) with basophilia, acute myelogenous leukemia (AML) with eosinophilia, and acute eosinophilic leukemia (AEL). It is characterized by a chromosomal translocation t(5,12)(q31,p13) that involves ETV6 and ACSL6.
Synonyms: Long-chain-fatty-acid--CoA ligase 6, Long-chain acyl-CoA synthetase 6, LACS 6
Molecular Weight 77680 DA
Gene ID 23305
UniProt ACSL6_HUMAN
Research Area Protein Modifications, Cancer, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Acyl-CoA Synthetase Long-Chain Family Member 6 (ACSL6) (AA 240-270), (Center) antibody The anti-FACL6 Pab (ABIN389115) is used in Western blot to detect FACL6 in mouse liver tissue lysate.
anti-Acyl-CoA Synthetase Long-Chain Family Member 6 (ACSL6) (AA 240-270), (Center) antibody (2) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Yagasaki, Jinnai, Yoshida et al.: "Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13)." in: Genes, chromosomes & cancer, Vol. 26, Issue 3, pp. 192-202, 2000 (PubMed).

Hosts (19)
Reactivities (19), (10), (8)
Applications (18), (10), (5), (2), (1), (1)
Epitopes (4), (1), (1), (1), (1)
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