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Details for Product No. ABIN389234

Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1) (AA 118-147), (Center) antibody

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Antigen
Synonyms CP26, CYP26, P450RAI, P450RAI1, Cyp26, P450RA, RAH, CYP26A, RACE, XCYP26A1, cyp26, xCYP26, cp26, p450rai, p450rai1
Epitope
»Alternatives AA 118-147, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN389234
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This CYP26A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-147 AA from the Central region of human CYP26A1.
Clone RB15025
Isotype Ig
Specificity This CYP26A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125~155 amino acids from the center region of human CYP26A1.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CYP26A1
Background CYP26A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues.
Synonyms: Cytochrome P450, family 26, subfamily A, polypeptide 1 (Cytochrome P450, family 26, subfamily A, polypeptide 1, isoform CRA_b), CYP26A1
Molecular Weight 56199 DA
Gene ID 1592
UniProt Q5VXI0
Research Area Stem Cells, Transcription Factors, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Quere, Baudet, Cassinat et al.: "Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity." in: Blood, Vol. 109, Issue 10, pp. 4450-60, 2007 (PubMed).

Lee, Perera, Coulter et al.: "The discovery of new coding alleles of human CYP26A1 that are potentially defective in the metabolism of all-trans retinoic acid and their assessment in a recombinant cDNA expression system." in: Pharmacogenetics and genomics, Vol. 17, Issue 3, pp. 169-80, 2007 (PubMed).

Alternatives for antigen "Cytochrome P450, Family 26, Subfamily A, Polypeptide 1 (CYP26A1)", type "Antibodies"
Hosts (31), (7), (3)
Reactivities (39), (21), (18), (12), (12), (12), (2), (2)
Applications (27), (18), (11), (10), (3), (3), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (8), (4), (2), (1), (1), (1), (1), (1)
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