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Details for Product No. ABIN389309

Ataxin 1 (ATXN1) (AA 754-781), (Ser776) antibody

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Synonyms ATX1, SCA1, D6S504E, 2900016G23Rik, Atx1, C85907, ENSMUSG00000074917, Gm10786, Sca1, sca1, ATXN1, ataxin 1b, atxn1, CG4547, Dmel\\CG4547, dAtx-1, dAtx1
»Alternatives AA 754-781, Ser776
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 2 references available
Catalog no. ABIN389309
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 AA from human ATXN1.
Clone RB16258
Isotype Ig
Specificity This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 761~791 amino acids surrounding S776 of human ATXN1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ATXN1
Background The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
Synonyms: Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Molecular Weight 86923 DA
Gene ID 6310
UniProt P54253
Research Area Stem Cells
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Lim, Crespo-Barreto, Jafar-Nejad et al.: "Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1." in: Nature, Vol. 452, Issue 7188, pp. 713-8, 2008 (PubMed).

Hong, Lee, Cho et al.: "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1." in: Biochemical and biophysical research communications, Vol. 371, Issue 2, pp. 256-60, 2008 (PubMed).

Alternatives for antigen "Ataxin 1 (ATXN1)", type "Antibodies"
Hosts (70), (47), (4), (3)
Reactivities (105), (101), (85), (26), (25), (25), (12)
Applications (72), (40), (35), (29), (26), (20), (16), (16), (5), (2), (1), (1)
Conjugates (7), (6), (6), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Epitopes (18), (18), (18), (12), (12), (4), (4), (2), (2), (1), (1)