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Ataxin 1 antibody (ATXN1) (AA 754-781)

Details for Product anti-ATXN1 Antibody No. ABIN389309, Supplier: Login to see
Antigen
  • ATXN1
  • SCA1
  • ataxin 1b
  • atxn1
  • CG4547
  • Dmel\\CG4547
  • dAtx-1
  • dAtx1
  • ATX1
  • D6S504E
  • 2900016G23Rik
  • Atx1
  • C85907
  • ENSMUSG00000074917
  • Gm10786
  • Sca1
  • sca1
Epitope
AA 754-781, Ser776
35
35
29
17
9
8
7
5
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
188
101
76
5
3
3
2
1
1
1
Host
Rabbit
101
87
10
3
Clonality (Clone)
Polyclonal ()
Conjugate
This Ataxin 1 antibody is un-conjugated
10
9
7
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
146
65
58
52
47
37
24
15
9
3
2
2
1
1
Supplier
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Immunogen This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 754-781 AA from human ATXN1.
Clone RB16258
Isotype Ig
Specificity This ATXN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 761~791 amino acids surrounding S776 of human ATXN1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ATXN1 (ATXN1 Antibody Abstract)
Background The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known.
Synonyms: Ataxin-1, Spinocerebellar ataxia type 1 protein, ATXN1, ATX1, SCA1
Molecular Weight 86923 DA
Gene ID 6310
UniProt P54253
Research Area Stem Cells
Pathways
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Ataxin 1 antibody (ATXN1) (AA 754-781) (ABIN389309) Western blot analysis of anti-ATXN1 Antibody (S776) (ABIN389309) in CEM cell line lys...
Immunofluorescence (IF) image for anti-Ataxin 1 antibody (ATXN1) (AA 754-781) (ABIN389309) Confocal immunofluorescent analysis of ATXN1 Antibody (S776)(ABIN389309) with hela ce...
Background publications Hong, Lee, Cho et al.: "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1." in: Biochemical and biophysical research communications, Vol. 371, Issue 2, pp. 256-60, 2008 (PubMed).

Lim, Crespo-Barreto, Jafar-Nejad et al.: "Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1." in: Nature, Vol. 452, Issue 7188, pp. 713-8, 2008 (PubMed).