24-Dehydrocholesterol Reductase (DHCR24) (AA 218-246), (Center) antibody

Details for Product No. ABIN389353
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Antigen
Synonyms mKIAA0018, 2310076D10Rik, 5830417J06Rik, DCE, Nbla03646, SELADIN1, seladin-1, MGC82737, zgc:101638
Epitope
AA 218-246, Center
(6), (3), (2), (2), (2)
Reactivity
Human
(30), (20), (17), (13), (12), (12)
Host
Rabbit
(31), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(23), (10), (7), (3), (3), (3), (2), (1), (1)
Pubmed 2 references available
Catalog no. ABIN389353
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This DHCR24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 AA from the Central region of human DHCR24.
Clone RB17629
Isotype Ig
Specificity This DHCR24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225~254 amino acids from the Center region of human DHCR24.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name DHCR24
Background DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. This protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in DHCR24 gene have been associated with desmosterolosis. Also, reduced expression of DHCR24 gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Synonyms: Diminuto/dwarf1 homolog, Seladin-1, 3-beta-hydroxysterol delta-24-reductase, 24-dehydrocholesterol reductase, DHCR24, KIAA0018
Molecular Weight 60101 DA
Gene ID 1718
UniProt Q15392
Research Area Stem Cells
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-24-Dehydrocholesterol Reductase (DHCR24) (AA 218-246), (Center) antibody Western blot analysis of anti-DHCR24 Antibody (Center)(ABIN389353) in HepG2 cell line lysates (35 µg/lane). DHCR24 (arrow) was detected using the purified polyclonal antibody.
Background publications Greeve, Hermans-Borgmeyer, Brellinger et al.: "The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 20, Issue 19, pp. 7345-52, 2000 (PubMed).

Waterham, Koster, Romeijn et al.: "Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis." in: American journal of human genetics, Vol. 69, Issue 4, pp. 685-94, 2001 (PubMed).

Hosts (31), (1)
Reactivities (30), (20), (17), (13), (12), (12)
Applications (23), (10), (7), (3), (3), (3), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (6), (3), (2), (2), (2)
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