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Details for Product No. ABIN389403

Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5) (C-Term), (AA 796-824) antibody

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Antigen
Synonyms FNRA, CD49e, VLA5A, Cd49e, Fnra, VLA5, Itga5_retired, ITGA5, CD11c
Epitope
»Alternatives C-Term, AA 796-824
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Flow Cytometry (FACS)
Pubmed 3 references available
Catalog no. ABIN389403
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-824 AA from the C-terminal region of human CD49e.
Clone RB18004
Isotype Ig
Specificity This CD49e antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 803~832 amino acids from the C-terminal region of human CD49e.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name CD49e
Background CD49e belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein is the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Synonyms: Integrin alpha-5, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49 antigen-like family member E, CD_antigen=CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5
Molecular Weight 114536 DA
Gene ID 3678
UniProt P08648
Research Area Stem Cells
Application Notes Recommend dilutions: WB : 1:1000,FC : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Schornberg, Shoemaker, Dube et al.: "Alpha5beta1-integrin controls ebolavirus entry by regulating endosomal cathepsins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 19, pp. 8003-8, 2009 (PubMed).

Okazaki, Ni, Ayeni et al.: "alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2378-87, 2009 (PubMed).

Boehmler, Drost, Jaggy et al.: "The CysLT1 ligand leukotriene D4 supports alpha4beta1- and alpha5beta1-mediated adhesion and proliferation of CD34+ hematopoietic progenitor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 11, pp. 6789-98, 2009 (PubMed).

Alternatives for antigen "Integrin, alpha 5 (Fibronectin Receptor, alpha Polypeptide) (ITGA5)", type "Antibodies"
Hosts (55), (52), (45), (41)
Reactivities (120), (94), (37), (14), (12), (3)
Applications (144), (49), (32), (28), (26), (20), (19), (15), (14), (10), (10), (3), (1), (1), (1)
Conjugates (34), (21), (13), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (4), (4), (4), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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