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Details for Product No. ABIN389865

C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1) (pTyr204) antibody

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Synonyms ABL, JTK7, p150, c-ABL, v-abl, bcr/abl, AI325092, Abl, E430008G22Rik, c-Abl, ABL1, CABL, ABLL, cb272
»Alternatives pTyr204
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Dot Blot (DB), Immunofluorescence (IF)
Pubmed 5 references available
Catalog no. ABIN389865
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This ABL Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL.
Clone RB7973
Isotype Ig
Specificity This Phospho-ABL-Y204 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y204 of human ABL.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ABL
Background ABL1 is a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Synonyms: Proto-oncogene tyrosine-protein kinase ABL1, p150, c-ABL, Abelson murine leukemia viral oncogene homolog 1, ABL1, ABL, JTK7
Molecular Weight 122873 DA
Gene ID 25
UniProt P00519
Research Area Apoptosis/Necrosis, Cancer, Cell Cycle, Phospho-specific antibodies, Cell Structure
Application Notes Recommend dilutions: DB : 1:500,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.37 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Aichberger, Mayerhofer, Krauth et al.: "Identification of mcl-1 as a BCR/ABL-dependent target in chronic myeloid leukemia (CML): evidence for cooperative antileukemic effects of imatinib and mcl-1 antisense oligonucleotides." in: Blood, Vol. 105, Issue 8, pp. 3303-11, 2005 (PubMed).

Wei, Li, Liu: "Insights into selective activation of p53 DNA binding by c-Abl." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12271-8, 2005 (PubMed).

Robinson, Martineau, Harris et al.: "Derivative chromosome 9 deletions are a significant feature of childhood Philadelphia chromosome positive acute lymphoblastic leukaemia." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 19, Issue 4, pp. 564-71, 2005 (PubMed).

Kim, Cho, Yoon et al.: "Interpretation of submicroscopic deletions of the BCR or ABL gene should not depend on extra signal-FISH: problems in interpretation of submicroscopic deletion of the BCR or ABL gene with extra signal-FISH." in: Genes, chromosomes & cancer, Vol. 43, Issue 1, pp. 37-44, 2005 (PubMed).

Barnes, McIntosh, Whetton et al.: "Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation." in: Oncogene, Vol. 24, Issue 20, pp. 3257-67, 2005 (PubMed).

Alternatives for antigen "C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1)", type "Antibodies"
Hosts (444), (26)
Reactivities (462), (340), (290), (204), (195), (180), (60), (48), (3), (1), (1)
Applications (244), (190), (167), (124), (79), (38), (24), (10), (9), (2), (1), (1), (1)
Conjugates (23), (20), (20), (19), (19), (19), (19), (19), (19), (19), (19)
Epitopes (41), (31), (30), (25), (21), (17), (14), (14), (14), (13), (13), (12), (12), (12), (12), (12), (12), (12), (8), (8), (7), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)